Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice
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12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in PlateletsHumanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets.Protease-activated receptor 4: from structure to function and back again.Drugs targeting protease-activated receptor-4 improve the anti-thrombotic therapeutic window.Perinatal lethality of Par4(-/-) mice delivered by primiparous dams reveals spontaneous bleeding in mice without platelet thrombin receptor function.Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood.The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
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P2860
Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice
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2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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2012年论文
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name
Safety and efficacy of targeti ...... ugs as antithrombotics in mice
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Safety and efficacy of targeti ...... ugs as antithrombotics in mice
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type
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Safety and efficacy of targeti ...... ugs as antithrombotics in mice
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Safety and efficacy of targeti ...... ugs as antithrombotics in mice
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Safety and efficacy of targeti ...... ugs as antithrombotics in mice
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Safety and efficacy of targeti ...... ugs as antithrombotics in mice
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P2093
P2860
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Safety and efficacy of targeti ...... ugs as antithrombotics in mice
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J K Mountford
J R Hamilton
S A Sturgeon
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P304
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10.1111/J.1476-5381.2012.01944.X
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2012-08-01T00:00:00Z