Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. - Wikidata - wikimedia - TriplyDB

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

http://www.wikidata.org/entity/Q47745236

about

Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses The Role of Gastrin and CCK Receptors in Pancreatic Cancer and other Malignancies The utility of transposon mutagenesis for cancer studies in the era of genome editing.Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance RASopathies: unraveling mechanisms with animal models The atypical PKCs in inflammation: NF-κB and beyond Preclinical Murine Models for Lung Cancer: Clinical Trial Applications Animal models of colorectal cancer Strategies to achieve conditional gene mutation in mice Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis RAS oncogenes: weaving a tumorigenic web Germline KRAS mutations cause Noonan syndrome Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications Menin determines K-RAS proliferative outputs in endocrine cells Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors A DNA transposon-based approach to validate oncogenic mutations in the mouse Ras oncogenes: split personalities Novel KRAS gene mutations in sporadic colorectal cancer Ras history: The saga continues.Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function.Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase Ras effector switching promotes divergent cell fates in C. elegans vulval patterning.Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer Minireview: physiological and pathological actions of RAS in the ovary.

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P2860

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

http://www.wikidata.org/entity/Q47745236

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Endogenous oncogenic K-ras

@nl

Endogenous oncogenic K-ras(G12 ...... tic and developmental defects.

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type

label

Endogenous oncogenic K-ras

@nl

Endogenous oncogenic K-ras(G12 ...... tic and developmental defects.

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prefLabel

Endogenous oncogenic K-ras

@nl

Endogenous oncogenic K-ras(G12 ...... tic and developmental defects.

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Endogenous oncogenic K-ras(G12 ...... stic and developmental defects

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Alice T Shaw

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Catrina King

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Daniel P Silver

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Denise Crowley

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Erica L Jackson

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Hanno Hock

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Kim L Mercer

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Lifu Wang

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Michael A Jacobetz

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Nicholas A Willis

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375-387

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scholarly article

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10.1016/S1535-6108(04)00085-6

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4

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5

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Sunil R Hingorani

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2004-04-01T00:00:00Z

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15093544

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