Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptorAtaxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neuronsThe human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membraneSignaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNFThe disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesionCellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous systemStructural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cellsIL-6 pathway in the liver: From physiopathology to therapyTherapeutic strategies for the clinical blockade of IL-6/gp130 signalingStructure of an extracellular gp130 cytokine receptor signaling complexCiliary neurotrophic factor induces acute-phase protein expression in hepatocytesDirect determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopyThe transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeProteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-GlycosylationInterplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammationSoluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responsesA disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptorIL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerContribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis.Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC coculturesInteraction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production.N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitisIL-6-trans-signalling increases rapid-eye-movement sleep in rats.Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencingDesigning cytokine variants by phage-display.Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes.Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage displayNovel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets.A designer hyper interleukin 11 (H11) is a biologically active cytokine.Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.Generation and function of the soluble interleukin-6 receptor.Introduction to stem cell biology in vitro. Threshold to the future.Instructive Role of the Microenvironment in Preventing Renal FibrosisThe IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.IL-6 type cytokine receptor complexes: hexamer, tetramer or both?Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
P50
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P50
description
deutscher Biochemiker und Hochschullehrer
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hulumtues
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researcher
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ricercatore
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wetenschapper
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հետազոտող
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name
Stefan Rose-John
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Stefan Rose-John
@de
Stefan Rose-John
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Stefan Rose-John
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Stefan Rose-John
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Stefan Rose-John
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type
label
Stefan Rose-John
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Stefan Rose-John
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Stefan Rose-John
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Stefan Rose-John
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Stefan Rose-John
@nl
Stefan Rose-John
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prefLabel
Stefan Rose-John
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Stefan Rose-John
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Stefan Rose-John
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Stefan Rose-John
@es
Stefan Rose-John
@nl
Stefan Rose-John
@sl
P569
P214
P227
P1053
A-7998-2010
P19
P21
P213
0000 0000 7799 3873
P214
P227
P31
P3829
P496
0000-0002-7519-3279
P569
1954-12-17T00:00:00Z
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viaf-120209694