ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

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ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

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ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

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ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

@en

ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

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ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

@en

ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

@nl

P1476

ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

@en

P2093

Jos H Beijnen

http://www.w3.org/2001/XMLSchema#string

Levi C M Buil

http://www.w3.org/2001/XMLSchema#string

Mark C de Gooijer

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P2860

Cell cycle, CDKs and cancer: a changing paradigm

Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months.

Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function.

MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.

The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma

MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma.

Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model

Pharmacokinetic assessment of efflux transport in sunitinib distribution to the brain.

Checkpoint control and cancer.

P2888

s10637-017-0539-8

P304

380-387

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P31

scholarly article

P356

10.1007/S10637-017-0539-8

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Olaf van Tellingen

P577

2017-11-17T00:00:00Z

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P698

29147815

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