The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma
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Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like CellsEfficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.Visualizing spatial distribution of alectinib in murine brain using quantitative mass spectrometry imagingFirst In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development.Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor modelSensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination RepairPharmacokinetic Properties of Anticancer Agents for the Treatment of Central Nervous System Tumors: Update of the Literature.Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma.Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer.Blood-brain barrier, cytotoxic chemotherapies and glioblastoma.Advances in drug delivery to high grade gliomas.WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner.Restricted Delivery of Talazoparib Across the Blood-Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma.Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma.Contraction of T cell richness in lung cancer brain metastases.Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma.GBM radiosensitizers: dead in the water…or just the beginning?ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.Jumping the Barrier: Modeling Drug Penetration across the Blood-Brain Barrier.Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach.The effect of regadenoson on the integrity of the human blood-brain barrier, a pilot study.Correlations of MGMT genetic polymorphisms with temozolomide resistance and prognosis of patients with malignant gliomas: a population-based study in China.
P2860
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P2860
The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma
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2015 nî lūn-bûn
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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
The Efficacy of the Wee1 Inhib ...... -Brain Barrier in Glioblastoma
@ast
The Efficacy of the Wee1 Inhib ...... -Brain Barrier in Glioblastoma
@en
type
label
The Efficacy of the Wee1 Inhib ...... -Brain Barrier in Glioblastoma
@ast
The Efficacy of the Wee1 Inhib ...... -Brain Barrier in Glioblastoma
@en
prefLabel
The Efficacy of the Wee1 Inhib ...... -Brain Barrier in Glioblastoma
@ast
The Efficacy of the Wee1 Inhib ...... -Brain Barrier in Glioblastoma
@en
P2093
P2860
P1476
The Efficacy of the Wee1 Inhib ...... -Brain Barrier in Glioblastoma
@en
P2093
Bennett Ma
Brett L Carlson
David Calligaris
Debra L Evans
Dennis O Iyekegbe
Dustin Mueller
Jann N Sarkaria
Jeanette E Eckel-Passow
Jenny L Pokorny
Katrina K Bakken
P2860
P304
P356
10.1158/1078-0432.CCR-14-2588
P407
P577
2015-01-21T00:00:00Z