Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.

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Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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Computationally-guided optimiz ...... 2 protein-protein interaction.

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Computationally-guided optimiz ...... 2 protein-protein interaction.

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Computationally-guided optimiz ...... 2 protein-protein interaction.

@en

Computationally-guided optimiz ...... 2 protein-protein interaction.

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Computationally-guided optimiz ...... 2 protein-protein interaction.

@en

Computationally-guided optimiz ...... 2 protein-protein interaction.

@nl

P1476

Computationally-guided optimiz ...... 2 protein-protein interaction.

@en

P2093

Grahame J McKenzie

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Jamie E Stokes

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P2860

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Human TPX2 is required for targeting Aurora-A kinase to the spindle

Predicting absolute ligand binding free energies to a simple model site

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

Rational methods for the selection of diverse screening compounds

Aurora-A kinase is essential for bipolar spindle formation and early development

P304

9372-9375

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scholarly article

P356

10.1039/C7CC05379G

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P407

English

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

P577

2017-08-01T00:00:00Z

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P698

28787041

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P921

computational biology

P932

5591577

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