Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design
about
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastomaDrugging MYCN through an allosteric transition in Aurora kinase AA Cell Biologist's Field Guide to Aurora Kinase InhibitorsDevelopment of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase InhibitorsInsights into Aurora-A Kinase Activation Using Unnatural Amino Acids Incorporated by Chemical ModificationAurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Structure of Aurora B–INCENP in complex with barasertib reveals a potential transinhibitory mechanismIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesDiverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modificationPseudokinases: update on their functions and evaluation as new drug targets.Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules.Issues in interpreting the in vivo activity of Aurora-AConformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors.Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergisticPten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.Aurora A kinase (AURKA) in normal and pathological cell division.On the molecular mechanisms of mitotic kinase activation.The structural mechanisms that underpin mitotic kinase activation.Switching Aurora-A kinase on and off at an allosteric site.Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophaseA water-mediated allosteric network governs activation of Aurora kinase A.Specificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions.Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.A new "angle" on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition.The structure of C290A:C393A Aurora A provides structural insights into kinase regulation.Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689.Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms.DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.The multifaceted allosteric regulation of Aurora kinase A.Dynamics of human protein kinase Aurora A linked to drug selectivityThe functional diversity of Aurora kinases: a comprehensive review
P2860
Q24296639-38ABA023-7B73-409A-9DE1-B8FA4A426444Q24303381-64EC1F11-7809-46F3-9C97-BF78604A0AD9Q27308125-94C1600B-12FF-4895-953B-E3B203D3980BQ27670770-90CA9F4B-6AE4-4A66-80D3-61B5DD721360Q27679437-D947F905-F5CA-4EA0-974A-8622EEFE54B1Q27680538-C43ED3F7-5D33-42EF-B236-010064A18830Q27682016-87DE4D7A-099F-4626-87D6-E0035B07901DQ28270556-050E82DE-C253-48DC-83A7-1AA977FB91BBQ28541635-F398A1CD-559A-4461-BF29-D5CD22131DB9Q30397636-7A9C8E9B-1D9E-4729-8017-815869AC125FQ31814812-DF7E4841-40D9-40D2-9BF0-05D1B6E5EB88Q34629643-21BBC6FF-8DDB-481D-8EF7-E690A721205DQ34964087-7C792BB2-52BB-41D3-8FF6-1D43F9657ED1Q35493874-30DBB577-F4AC-4FCE-B4E6-21941E2BAFC9Q35591349-873D75F7-7C83-42C6-9D22-5481470CD69FQ35668733-98C038BF-5302-4295-9FC0-EC4CC21FD830Q36071656-41C5E89C-8AE0-4966-B8BC-0CFDB79E14F4Q36715681-A3BB0C75-18DF-42FB-A5BB-0C6A2AB53967Q38066194-E705A168-2250-4E68-9FAE-0E8E328B4139Q38122237-058A84FB-88C9-4D4E-8510-76D9E8288044Q39200217-71701623-7BD6-4B55-9788-229D7B628BABQ39834525-486CF133-EAAD-4A37-8DE6-9CC784DAA213Q41654097-55164484-5D44-4480-A12B-6C824F491BF4Q41717003-A9E6653B-741D-4EAF-B4D5-D52524CAE3BFQ41868025-6E2AB1DD-640A-427B-A061-BA2DD9424954Q42083680-68889C5B-11AE-472A-A66C-6B4329C9F316Q42101067-BBCBFFF7-A4BC-4088-BB20-A734CB6EAC1FQ42359642-3CBA917B-40D8-4D21-BB3D-8CB89D9E1426Q42430705-17455A5C-0982-4AAE-8604-86A97724E39BQ46264711-682AEC5A-1F83-472B-965F-8CE2A062BD30Q47979119-6298E675-9217-4D8E-9AA1-DDA2E7619751Q50861755-A5955C3F-ED3F-405D-AB6A-71BC16F0249CQ52619102-55A12CA3-DBD5-4500-AB33-3AFB44F1C22DQ54313399-780EDD23-097A-442A-A21B-1AF6BB8C6BA3Q55486788-33A03C3B-0C2E-4A81-B8CC-C025A567658AQ56889888-F78EB6AB-C504-45D1-A421-F1C1366C3659Q58719157-872E76A4-748D-485D-AA2F-141B619BB64B
P2860
Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Crystal structure of an Aurora ...... to selectivity and drug design
@ast
Crystal structure of an Aurora ...... to selectivity and drug design
@en
Crystal structure of an Aurora ...... to selectivity and drug design
@en-gb
Crystal structure of an Aurora ...... to selectivity and drug design
@nl
type
label
Crystal structure of an Aurora ...... to selectivity and drug design
@ast
Crystal structure of an Aurora ...... to selectivity and drug design
@en
Crystal structure of an Aurora ...... to selectivity and drug design
@en-gb
Crystal structure of an Aurora ...... to selectivity and drug design
@nl
prefLabel
Crystal structure of an Aurora ...... to selectivity and drug design
@ast
Crystal structure of an Aurora ...... to selectivity and drug design
@en
Crystal structure of an Aurora ...... to selectivity and drug design
@en-gb
Crystal structure of an Aurora ...... to selectivity and drug design
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Crystal structure of an Aurora ...... to selectivity and drug design
@en
P2093
Butrus Atrash
Julian Blagg
Magda Kosmopoulou
Vassilios Bavetsias
P2860
P3181
P356
10.1042/BJ20091530
P407
P577
2010-03-15T00:00:00Z