Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain.
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Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cellsSignal-dependent membrane targeting by pleckstrin homology (PH) domainsIdentification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast.Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphateHuman Emt tyrosine kinase is specifically expressed both in mature T-lymphocytes and T-cell associated hematopoietic malignanciesThe Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent mannerThe actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity.Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.Disrupting the intermolecular self-association of Itk enhances T cell signaling.A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selectionImaging phosphoinositide dynamics using GFP-tagged protein domains.Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.Clinical characteristics and genetic profiles of 174 patients with X-linked agammaglobulinemia: Report from Shanghai, China (2000-2015).Conformational snapshots of Tec kinases during signaling.Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity.PI3K and STAT3: a new alliance.Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BPChemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases.Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain.The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97.Molecular dynamic simulation to explore the molecular basis of Btk-PH domain interaction with Ins(1,3,4,5)P4.New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B
P2860
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P2860
Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Characterization of the plecks ...... osphoinositide binding domain.
@en
Characterization of the plecks ...... osphoinositide binding domain.
@nl
type
label
Characterization of the plecks ...... osphoinositide binding domain.
@en
Characterization of the plecks ...... osphoinositide binding domain.
@nl
prefLabel
Characterization of the plecks ...... osphoinositide binding domain.
@en
Characterization of the plecks ...... osphoinositide binding domain.
@nl
P2093
P356
P1476
Characterization of the plecks ...... osphoinositide binding domain.
@en
P2093
P304
P356
10.1006/BBRC.1997.6947
P407
P577
1997-07-01T00:00:00Z