Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.
about
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CARPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 miceA brief history of the discovery of PXR and CAR as xenobiotic receptorsThe repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 geneGene structure of CYP2C8 and extrahepatic distribution of the human CYP2CsFunctional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1.Tissue-specific chromatin structure of the phenobarbital-responsive unit and proximal promoter of CYP2B1/2 and modulation by phenobarbital.Phenobarbital-mediated changes in gene expression in the liver.The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene.Regulation of cytochrome P450 (CYP) genes by nuclear receptors.Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profilingXenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesUpregulation of cytochromes P450 2B in rat liver by orphenadrine.Nuclear receptors CAR and PXR in the regulation of hepatic metabolism.Deciphering the roles of the constitutive androstane receptor in energy metabolism.The Nrf2 activator oltipraz also activates the constitutive androstane receptor.The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription.Glucocorticoids and phenobarbital induce murine CYP2B genes by independent mechanisms.Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor beta and the liver X receptor.A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line.Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases.Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness.Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response.Cytochrome P450s CYP6D3 and CYP6D1 are part of a P450 gene cluster on autosome 1 in the house fly.Phenobarbital alters protein binding to the CYP2B1/2 phenobarbital-responsive unit in native chromatin.Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes.Localization of estradiol-responsive region in the phenobarbital-responsive enhancer module of mouse Cyp2b-10 gene.Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo.Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs.Constitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues.In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.Identification and characterization of a novel tissue-specific transcriptional activating element in the 5'-flanking region of the CYP2A3 gene predominantly expressed in rat olfactory mucosa.Impact of CAR agonist ligand TCPOBOP on mouse liver chromatin accessibility.
P2860
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P2860
Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Characterization of a phenobar ...... le in mouse P450 Cyp2b10 gene.
@en
Characterization of a phenobar ...... le in mouse P450 Cyp2b10 gene.
@nl
type
label
Characterization of a phenobar ...... le in mouse P450 Cyp2b10 gene.
@en
Characterization of a phenobar ...... le in mouse P450 Cyp2b10 gene.
@nl
prefLabel
Characterization of a phenobar ...... le in mouse P450 Cyp2b10 gene.
@en
Characterization of a phenobar ...... le in mouse P450 Cyp2b10 gene.
@nl
P2860
P356
P1476
Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene
@en
P2093
P2860
P304
14943-14949
P356
10.1074/JBC.272.23.14943
P407
P577
1997-06-01T00:00:00Z