about
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity.Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library.Regulation of cytochrome P450 (CYP) genes by nuclear receptors.Effluxing ABC transporters in human corneal epithelium.Use of comprehensive screening methods to detect selective human CAR activators.Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding siteLigand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies.Evaluating collaborative planning methods supporting programme-based planning in natural resource management.Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.Regulation of gene expression by CAR: an update.Inhibition of BET bromodomains alleviates inflammation in human RPE cells.Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.Improved assays for xenosensor activation based on reverse transfection.Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.Characterization of human cytochrome P450 induction by pesticides.New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists.Monocarboxylate transport in human corneal epithelium and cell lines.Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy.Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells.Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines.Amino acids important for ligand specificity of the human constitutive androstane receptor.Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons.A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells.Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists.DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.Effects of triaryl phosphates on mouse and human nuclear receptors.Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship.Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor.In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.Molecular dynamics simulations for human CAR inverse agonists.Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells.A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine.Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Paavo Honkakoski
@ast
Paavo Honkakoski
@en
Paavo Honkakoski
@es
Paavo Honkakoski
@nl
Paavo Honkakoski
@sl
type
label
Paavo Honkakoski
@ast
Paavo Honkakoski
@en
Paavo Honkakoski
@es
Paavo Honkakoski
@nl
Paavo Honkakoski
@sl
prefLabel
Paavo Honkakoski
@ast
Paavo Honkakoski
@en
Paavo Honkakoski
@es
Paavo Honkakoski
@nl
Paavo Honkakoski
@sl
P106
P1153
7004749265
P31
P496
0000-0002-4332-3577