Sequential interchange of four amino acids from blood group B to blood group A glycosyltransferase boosts catalytic activity and progressively modifies substrate recognition in human recombinant enzymes.
about
Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferaseStructural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferaseABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changesSubstrate and Metal Ion Promiscuity in Mannosylglycerate SynthaseSequence-dependent effects of cryoprotectants on the active sites of the human ABO(H) blood group A and B glycosyltransferasesBase-modified Donor Analogues Reveal Novel Dynamic Features of a GlycosyltransferaseStructures of Complexes of a Metal-independent Glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-Acetylgalactosamine (UDP-GalNAc) and Its Hydrolysis ProductsStructures of a human blood group glycosyltransferase in complex with a photo-activatable UDP-Gal derivative reveal two different binding conformationsDesign of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogateCharacterization of cysteine residues and disulfide bonds in proteins by liquid chromatography/electrospray ionization tandem mass spectrometry.Etiological point mutations in the hereditary multiple exostoses gene EXT1: a functional analysis of heparan sulfate polymerase activityA glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding.Affinities of human histo-blood group antigens for norovirus capsid protein complexes.Bioconjugation and detection of lactosamine moiety using alpha1,3-galactosyltransferase mutants that transfer C2-modified galactose with a chemical handle.Novel UDP-GalNAc Derivative Structures Provide Insight into the Donor Specificity of Human Blood Group Glycosyltransferase.Cloning and transcriptional regulation of genes responsible for synthesis of gangliosides.Glycosyltransferase engineering for carbohydrate synthesis.Expression of the histo-blood group B gene predominates in AB-genotype cells.Intracellular inhibition of blood group A glycosyltransferase.High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise MannerA single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase.Structural basis for the inactivity of human blood group O2 glycosyltransferase.Donor substrate specificity of recombinant human blood group A, B and hybrid A/B glycosyltransferases expressed in Escherichia coli.Kinetic studies on Korean serum cis-AB enzymes reveal diminished A and B transferase activities.A novel A allele with 664G>A mutation identified in a family with the Am phenotype.
P2860
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P2860
Sequential interchange of four amino acids from blood group B to blood group A glycosyltransferase boosts catalytic activity and progressively modifies substrate recognition in human recombinant enzymes.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Sequential interchange of four ...... in human recombinant enzymes.
@en
Sequential interchange of four ...... in human recombinant enzymes.
@nl
type
label
Sequential interchange of four ...... in human recombinant enzymes.
@en
Sequential interchange of four ...... in human recombinant enzymes.
@nl
prefLabel
Sequential interchange of four ...... in human recombinant enzymes.
@en
Sequential interchange of four ...... in human recombinant enzymes.
@nl
P2093
P2860
P356
P1476
Sequential interchange of four ...... in human recombinant enzymes.
@en
P2093
P2860
P304
14133-14138
P356
10.1074/JBC.272.22.14133
P407
P577
1997-05-01T00:00:00Z