Cloning and characterization of a Dictyostelium myosin I heavy chain kinase activated by Cdc42 and Rac.
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Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinaseA role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex.Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.PakB binds to the SH3 domain of Dictyostelium Abp1 and regulates its effects on cell polarity and early development.Functional analysis of tail domains of Acanthamoeba myosin IC by characterization of truncation and deletion mutants.The myosin I SH3 domain and TEDS rule phosphorylation site are required for in vivo functionMyosin I overexpression impairs cell migrationA potentially exhaustive screening strategy reveals two novel divergent myosins in Dictyostelium.Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakBRacF1, a novel member of the Rho protein family in Dictyostelium discoideum, associates transiently with cell contact areas, macropinosomes, and phagosomes.Recruitment of a specific amoeboid myosin I isoform to the plasma membrane in chemotactic Dictyostelium cells.TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p.Analysis of the regulatory phosphorylation site in Acanthamoeba myosin IC by using site-directed mutagenesisHow many is enough? Exploring the myosin repertoire in the model eukaryote Dictyostelium discoideum.Myosin I is required for hypha formation in Candida albicans.Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s)In vivo function of class I myosins.Myosin I heavy chain kinase: cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42.p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin Ip21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts.PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.Identification by mass spectrometry of the phosphorylated residue responsible for activation of the catalytic domain of myosin I heavy chain kinase, a member of the PAK/STE20 familyPakD, a putative p21-activated protein kinase in Dictyostelium discoideum, regulates actin.Function and regulation of Saccharomyces cerevisiae myosins-I in endocytic budding.Dictyostelium PAKc is required for proper chemotaxis.Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading.ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts.The Dictyostelium class I myosin, MyoD, contains a novel light chain that lacks high-affinity calcium-binding sites.Myosin I phosphorylation is increased by chemotactic stimulation.Calmodulin-binding and autoinhibitory domains of Acanthamoeba myosin I heavy chain kinase, a p21-activated kinase (PAK).Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1.Regulation of the p21-activated kinase-related Dictyostelium myosin I heavy chain kinase by autophosphorylation, acidic phospholipids, and Ca2+-calmodulin.Constitutive activation of endocytosis by mutation of myoA, the myosin I gene of Aspergillus nidulans.Characterization and cloning of a Dictyostelium Ste20-like protein kinase that phosphorylates the actin-binding protein severin.The catalytic domain of acanthamoeba myosin I heavy chain kinase. II. Expression of active catalytic domain and sequence homology to p21-activated kinase (PAK).Activation of myosin-I by members of the Ste20p protein kinase family.Novel Dictyostelium unconventional myosin, MyoM, has a putative RhoGEF domain.The Phosphorylation Site for Ste20p-like Protein Kinases Is Essential for the Function of Myosin-I in Yeast
P2860
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P2860
Cloning and characterization of a Dictyostelium myosin I heavy chain kinase activated by Cdc42 and Rac.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Cloning and characterization o ...... se activated by Cdc42 and Rac.
@en
Cloning and characterization o ...... se activated by Cdc42 and Rac.
@nl
type
label
Cloning and characterization o ...... se activated by Cdc42 and Rac.
@en
Cloning and characterization o ...... se activated by Cdc42 and Rac.
@nl
prefLabel
Cloning and characterization o ...... se activated by Cdc42 and Rac.
@en
Cloning and characterization o ...... se activated by Cdc42 and Rac.
@nl
P2093
P2860
P356
P1476
Cloning and characterization o ...... se activated by Cdc42 and Rac.
@en
P2093
P2860
P304
27044-27048
P356
10.1074/JBC.271.43.27044
P407
P577
1996-10-01T00:00:00Z