Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts.
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Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activityNegative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferationAssembly and function of a cytosolic form of NADH-specific isocitrate dehydrogenase in yeast.Fas Versatile Signaling and Beyond: Pivotal Role of Tyrosine Phosphorylation in Context-Dependent Signaling and DiseasesThe protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 cateninPhosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signalingLarge-scale sequencing in human chromosome 12p13: experimental and computational gene structure determinationSrc homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells.Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view.Leishmania interferes with host cell signaling to devise a survival strategy.SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.SHP-1 is a target of regorafenib in colorectal cancer.Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humansAlteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses.Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter.Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growthNegative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoproteinPromoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS gliaPharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer.Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through.Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling.Protein tyrosine phosphatases: regulatory mechanisms.Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotypeInterferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.Expression of different functional isoforms in haematopoiesis.Evasion of Host Defence by Leishmania donovani: Subversion of Signaling Pathways.MicroRNA-378g enhanced radiosensitivity of NPC cells partially by targeting protein tyrosine phosphatase SHP-1.SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma.Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.SHP-1 promoter 2 methylation in cerebrospinal fluid for diagnosis of leptomeningeal epithelial-derived malignancy (carcinomatous meningitis).Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy.Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.Molecular mechanisms underlying SHP-1 gene expression.Gene expression of the hematopoietic cell phosphatase in juvenile myelomonocytic leukemia.
P2860
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P2860
Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Human protein tyrosine phospha ...... generate multiple transcripts.
@en
Human protein tyrosine phosphatase 1C
@nl
type
label
Human protein tyrosine phospha ...... generate multiple transcripts.
@en
Human protein tyrosine phosphatase 1C
@nl
prefLabel
Human protein tyrosine phospha ...... generate multiple transcripts.
@en
Human protein tyrosine phosphatase 1C
@nl
P2093
P356
P1433
P1476
Human protein tyrosine phospha ...... generate multiple transcripts.
@en
P2093
P304
P356
10.1006/GENO.1995.1020
P577
1995-05-01T00:00:00Z