Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. - Wikidata - wikimedia - TriplyDB

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

http://www.wikidata.org/entity/Q48088931

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A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose Insights into obesity and diabetes at the intersection of mouse and human genetics Genetic and epigenetic control of metabolic health Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress Hyperglycemia in apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility.Evidence of maternal QTL affecting growth and obesity in adult mice Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus.Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network.A genome-wide library of CB4856/N2 introgression lines of Caenorhabditis elegans.Leptin receptor modulation of adiposity and fertility Metabolic syndrome: from epidemiology to systems biology.A wild derived quantitative trait locus on mouse chromosome 2 prevents obesity.Genetics. Systems genetics.Metabolic syndrome components in murine models.Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study).Endurance Exercise Ability in the Horse: A Trait with Complex Polygenic Determinism.Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations.Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.Subcongenic analysis of tabw2 obesity QTL on mouse chromosome 6.BTBR Ob/Ob mutant mice model progressive diabetic nephropathy.Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice.A model selection approach for expression quantitative trait loci (eQTL) mapping Altered pancreatic growth and insulin secretion in WSB/EiJ mice.Personalized epigenomic signatures that are stable over time and covary with body mass index High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity.Effects of CP-900691, a novel peroxisome proliferator-activated receptor α, agonist on diabetic nephropathy in the BTBR ob/ob mouse Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11.Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism.Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.

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Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

http://www.wikidata.org/entity/Q48088931

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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name

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

@en

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

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type

label

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

@en

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

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prefLabel

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

@en

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

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P1433

Nature Genetics

P1476

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

@en

P2093

Alan D Attie

http://www.w3.org/2001/XMLSchema#string

Brian S Yandell

http://www.w3.org/2001/XMLSchema#string

Daniel M Klass

http://www.w3.org/2001/XMLSchema#string

Donald S Stapleton

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Edward A Kabara

http://www.w3.org/2001/XMLSchema#string

Eric T-K Mui

http://www.w3.org/2001/XMLSchema#string

Hong Lan

http://www.w3.org/2001/XMLSchema#string

Igor Boronenkov

http://www.w3.org/2001/XMLSchema#string

Jonathan P Stoehr

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Kathryn M Schueler

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P2860

The genes for the human VPS10 domain-containing receptors are large and contain many small exons

Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells

Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action

R/qtl: QTL mapping in experimental crosses

Functional organization of the sortilin Vps10p domain.

SorCS3 does not require propeptide cleavage to bind nerve growth factor.

Genetic epidemiology of diabetes.

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans.

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688-693

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10.1038/NG1796

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P433

6

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38

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Philipp W Raess

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2006-05-07T00:00:00Z

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7098166

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16682971

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P921

type-2 diabetes