Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A.
about
Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartmentsA neuronal function of the tumor suppressor protein merlinStructure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and SelectivityLocalization and quaternary structure of the PKA RI holoenzymeCyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerizationMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalA functional association between merlin and HEI10, a cell cycle regulator.Neuronal microtubule-associated protein 2D is a dual a-kinase anchoring protein expressed in rat ovarian granulosa cells.Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer)Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.Merlin and the ERM proteins in Schwann cells, neurons and growth cones.cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain.Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics.Scaffolding during the cell cycle by A-kinase anchoring proteins.Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor.Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I.Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton.
P2860
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P2860
Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A.
description
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name
Merlin links to the cAMP neuro ...... a subunit of protein kinase A.
@en
Merlin links to the cAMP neuro ...... a subunit of protein kinase A.
@nl
type
label
Merlin links to the cAMP neuro ...... a subunit of protein kinase A.
@en
Merlin links to the cAMP neuro ...... a subunit of protein kinase A.
@nl
prefLabel
Merlin links to the cAMP neuro ...... a subunit of protein kinase A.
@en
Merlin links to the cAMP neuro ...... a subunit of protein kinase A.
@nl
P2093
P2860
P50
P356
P1476
Merlin links to the cAMP neuro ...... a subunit of protein kinase A.
@en
P2093
Cathrine R Carlson
Juha Kuja-Panula
Kaija Alfthan
Lutz Vossebein
Olli Carpén
Tambet Teesalu
P2860
P304
41167-41172
P356
10.1074/JBC.M306149200
P407
P577
2003-08-01T00:00:00Z