3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.
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Neuropharmacology of alcohol addictionAcute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?Stress, dysregulation of drug reward pathways, and the transition to drug dependenceChronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapseCorticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanismA role for brain stress systems in addiction.Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumptionRole of cues and contexts on drug-seeking behaviourAnimal models of post-traumatic stress disorder and recent neurobiological insights.Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior.Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism.A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegansAn Update on CRF Mechanisms Underlying Alcohol Use Disorders and DependenceA novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in ratsStress-Induced Reinstatement of Drug Seeking: 20 Years of Progress.Synaptic effects induced by alcohol.Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats.The Interplay between the Hippocampus and Amygdala in Regulating Aberrant Hippocampal Neurogenesis during Protracted Abstinence from Alcohol Dependence.Corticotropin-releasing factor acting on corticotropin-releasing factor receptor type 1 is critical for binge alcohol drinking in mice.Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder.Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal modelsRole of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention.Effects of stress on alcohol drinking: a review of animal studies.Progress in corticotropin-releasing factor-1 antagonist development.The role of CRF and CRF-related peptides in the dark side of addiction.Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fearNeurobiological mechanisms of addiction: focus on corticotropin-releasing factor.Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapseCorticotropin releasing factor receptor antagonists for major depressive disorder.Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues.Dynamic association between negative affect and alcohol lapses following alcohol treatmentUrocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference.Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathwayIntensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice.Corticotropin releasing factor: a key role in the neurobiology of addictionH2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence.Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate
P2860
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P2860
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
3-(4-Chloro-2-morpholin-4-yl-t ...... n animal models of alcoholism.
@en
3-(4-Chloro-2-morpholin-4-yl-t ...... n animal models of alcoholism.
@nl
type
label
3-(4-Chloro-2-morpholin-4-yl-t ...... n animal models of alcoholism.
@en
3-(4-Chloro-2-morpholin-4-yl-t ...... n animal models of alcoholism.
@nl
prefLabel
3-(4-Chloro-2-morpholin-4-yl-t ...... n animal models of alcoholism.
@en
3-(4-Chloro-2-morpholin-4-yl-t ...... n animal models of alcoholism.
@nl
P2093
P1476
3-(4-Chloro-2-morpholin-4-yl-t ...... in animal models of alcoholism
@en
P2093
Andrea Cippitelli
Anh Dzung Lê
Chafiq Hamdouchi
David McKinzie
Donald R Gehlert
Erik J Hembre
Jeffrey Cramer
Jianliang Lu
Markus Heilig
Michelle Morin
P304
P356
10.1523/JNEUROSCI.4985-06.2007
P407
P577
2007-03-01T00:00:00Z