The pharmacokinetic principles behind scaling from preclinical results to phase I protocols.
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Safety and pharmacokinetics of intravenous zanamivir treatment in hospitalized adults with influenza: an open-label, multicenter, single-arm, phase II studyComprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug developmentPharmacokinetics and clearance processes of UK-279,276 (rNIF) in rat and dog: comparison with human data.A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation.Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment.Metabolism and disposition of 3,4-methylenedioxymethamphetamine ("ecstasy") in baboons after oral administration: comparison with humans reveals marked differences.PEGylated DX-1000: pharmacokinetics and antineoplastic activity of a specific plasmin inhibitor.Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumors.Preclinical Modeling of Tumor Growth and Angiogenesis Inhibition to Describe Pazopanib Clinical Effects in Renal Cell Carcinoma.The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects.On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Interspecies allometric meta-analysis of the comparative pharmacokinetics of 85 drugs across veterinary and laboratory animal species.Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.Clearance of fentanyl, alfentanil, methohexitone, thiopentone and ketamine in relation to estimated hepatic blood flow in several animal species: application to prediction of clearance in man.Allometric scaling of pegylated liposomal anticancer drugs.Factors that Impact the Developability of Drug CandidatesPharmacokinetics and Pharmacodynamics of Peptide and Protein Drugs
P2860
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P2860
The pharmacokinetic principles behind scaling from preclinical results to phase I protocols.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
The pharmacokinetic principles ...... results to phase I protocols.
@en
The pharmacokinetic principles ...... results to phase I protocols.
@nl
type
label
The pharmacokinetic principles ...... results to phase I protocols.
@en
The pharmacokinetic principles ...... results to phase I protocols.
@nl
prefLabel
The pharmacokinetic principles ...... results to phase I protocols.
@en
The pharmacokinetic principles ...... results to phase I protocols.
@nl
P1476
The pharmacokinetic principles ...... results to phase I protocols.
@en
P2093
P356
10.2165/00003088-199936010-00001
P577
1999-01-01T00:00:00Z
P6179
1050839926