Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.
about
Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy.Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration.New (benz)imidazolopyridino tacrines as nonhepatotoxic, cholinesterase inhibitors for Alzheimer disease.Natural antioxidants in hybrids for the treatment of neurodegenerative diseases: a successful strategy?Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics for Alzheimer's Disease.Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease.Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological TreatmentImidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy.Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site.Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors.Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore.Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer's disease.Profiling donepezil template into multipotent hybrids with antioxidant properties.Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.
P2860
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P2860
Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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2014年學術文章
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name
Novel tacrine-grafted Ugi addu ...... tacrine-ferulic acid hybrids.
@en
Novel tacrine-grafted Ugi addu ...... tacrine-ferulic acid hybrids.
@nl
type
label
Novel tacrine-grafted Ugi addu ...... tacrine-ferulic acid hybrids.
@en
Novel tacrine-grafted Ugi addu ...... tacrine-ferulic acid hybrids.
@nl
prefLabel
Novel tacrine-grafted Ugi addu ...... tacrine-ferulic acid hybrids.
@en
Novel tacrine-grafted Ugi addu ...... tacrine-ferulic acid hybrids.
@nl
P2093
P2860
P50
P356
P1433
P1476
Novel tacrine-grafted Ugi addu ...... tacrine-ferulic acid hybrids.
@en
P2093
Bernard Refouvelet
Clara Herrera-Arozamena
Elena Soriano
José Marco-Contelles
Lhassane Ismaili
Lucía de Andrés
Marc Pudlo
Maria Laura Bolognesi
Michael Decker
Sarah Wehle
P2860
P304
P356
10.1002/CMDC.201402409
P50
P577
2014-12-23T00:00:00Z