Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. - Wikidata - wikimedia - TriplyDB

Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity.

Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity.

http://www.wikidata.org/entity/Q48692801

about

Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae Conus peptides: biodiversity-based discovery and exogenomics.Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus Increase of sodium channels (nav 1.8 and nav 1.9) in rat dorsal root ganglion neurons exposed to autologous nucleus pulposus.The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins.Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion.Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel The roles of sodium channels in nociception: Implications for mechanisms of pain Conotoxin gene superfamilies.μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB.Animal toxins can alter the function of Nav1.8 and Nav1.9.Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons NaV1.8 channels are expressed in large, as well as small, diameter sensory afferent neurons.Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.Voltage-gated sodium channel blockers for the treatment of neuropathic pain.NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons Isoform-selective voltage-gated Na(+) channel modulators as next-generation analgesics.Therapeutic potential of conopeptides.Animal toxins influence voltage-gated sodium channel function.Therapeutic conotoxins: a US patent literature survey.Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics.Molecular Engineering of Conus Peptides as Therapeutic Leads.Sodium channels and pain: from toxins to therapies.Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.The GeneTrawler: mapping potential drug targets in human and rat tissues.Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails.

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P2860

Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity.

http://www.wikidata.org/entity/Q48692801

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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name

Synthetic muO-conotoxin MrVIB ...... ng-lasting analgesic activity.

@en

Synthetic muO-conotoxin MrVIB ...... ng-lasting analgesic activity.

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type

label

Synthetic muO-conotoxin MrVIB ...... ng-lasting analgesic activity.

@en

Synthetic muO-conotoxin MrVIB ...... ng-lasting analgesic activity.

@nl

prefLabel

Synthetic muO-conotoxin MrVIB ...... ng-lasting analgesic activity.

@en

Synthetic muO-conotoxin MrVIB ...... ng-lasting analgesic activity.

@nl

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Baldomero M Olivera

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Brad R Green

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Brian D Klein

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Brian Fiedler

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Doju Yoshikami

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Grzegorz Bulaj

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Heinrich Terlau

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Jacob S Nielsen

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John D Wagstaff

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Linda Chicoine

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scholarly article

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10.1021/BI060159+

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23

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