Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
about
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancersPhosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neuronsRegulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylationRegulation of peroxiredoxin I activity by Cdc2-mediated phosphorylationCdc2: a monopotent or pluripotent CDK?Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosisInvolvement of SIRT7 in resumption of rDNA transcription at the exit from mitosisRoscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteinsA novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation.Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4Cdc25B functions as a novel coactivator for the steroid receptorsBiphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytesRoscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factorsSpecific small molecule inhibitors of Skp2-mediated p27 degradationS-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptideThe selectivity of protein kinase inhibitors: a further updateHyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer diseaseCyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1MCAK associates with the tips of polymerizing microtubulesGenomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridolMultiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5.Roscovitine in cancer and other diseasesNeuroprotection for traumatic brain injuryScreening marine resources to find novel chemical inhibitors of disease-relevant protein kinasesIntermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ LineCdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem CellsPhosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replicationDissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell lineCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsGetting to S: CDK functions and targets on the path to cell-cycle commitmentRequirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesisAspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culturep35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interactionStem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryoTip60 acetyltransferase activity is controlled by phosphorylationThe human nuclear SRcyp is a cell cycle-regulated cyclophilinInhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitorsPosttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localizep21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.Rapamycin inhibits didemnin B-induced apoptosis in human HL-60 cells: evidence for the possible involvement of FK506-binding protein 25
P2860
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P2860
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Biochemical and cellular effec ...... t kinases cdc2, cdk2 and cdk5.
@en
Biochemical and cellular effec ...... t kinases cdc2, cdk2 and cdk5.
@nl
type
label
Biochemical and cellular effec ...... t kinases cdc2, cdk2 and cdk5.
@en
Biochemical and cellular effec ...... t kinases cdc2, cdk2 and cdk5.
@nl
prefLabel
Biochemical and cellular effec ...... t kinases cdc2, cdk2 and cdk5.
@en
Biochemical and cellular effec ...... t kinases cdc2, cdk2 and cdk5.
@nl
P2093
P50
P1433
P1476
Biochemical and cellular effec ...... nt kinases cdc2, cdk2 and cdk5
@en
P2093
P304
P356
10.1111/J.1432-1033.1997.T01-2-00527.X
P407
P577
1997-01-01T00:00:00Z