about
Characterization of phosphofructokinase activity in Mycobacterium tuberculosis reveals that a functional glycolytic carbon flow is necessary to limit the accumulation of toxic metabolic intermediates under hypoxiaCytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogasterBiochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosisVariations of Subunit of the Mycobacterium tuberculosis F1Fo ATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stressesVitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosisIdentification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosisExploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteriaPharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosisThe spectrum of latent tuberculosis: rethinking the biology and intervention strategiesTowards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome.Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.Rifabutin Is Active against Mycobacterium abscessus Complex.Draft Genome Sequence of Mycobacterium abscessus BambooIn Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin.Mycobacterium bovis BCG recA deletion mutant shows increased susceptibility to DNA-damaging agents but wild-type survival in a mouse infection model.para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosisPeptide deformylase inhibitors as potent antimycobacterial agents.Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteriaA high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosisFragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria.Developmental transcriptome of resting cell formation in Mycobacterium smegmatis.Eagle Effect in Nonreplicating Persister MycobacteriaA novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agentsBoromycin Kills Mycobacterial Persisters without Detectable ResistanceThe protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosisMild Nutrient Starvation Triggers the Development of a Small-Cell Survival Morphotype in Mycobacteria.Rel Is Required for Morphogenesis of Resting Cells in Mycobacterium smegmatis.Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase.Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosisMycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease.How Mycobacterium tuberculosis goes to sleep: the dormancy survival regulator DosR a decade later.Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.Reactive dirty fragments: implications for tuberculosis drug discovery.Future target-based drug discovery for tuberculosis?Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
@hy
name
Thomas Dick
@ast
Thomas Dick
@en
Thomas Dick
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Thomas Dick
@nl
Thomas Dick
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type
label
Thomas Dick
@ast
Thomas Dick
@en
Thomas Dick
@es
Thomas Dick
@nl
Thomas Dick
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prefLabel
Thomas Dick
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Thomas Dick
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Thomas Dick
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Thomas Dick
@nl
Thomas Dick
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P106
P1153
7102341159
P21
P2798
P31
P3835
thomas-dick2
P496
0000-0002-9604-9452
P569
2000-01-01T00:00:00Z