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The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoaMolecular architecture of 4E-BP translational inhibitors bound to eIF4ETNF-alpha regulates the effects of irradiation in the mouse bone marrow microenvironment.Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis.CUP promotes deadenylation and inhibits decapping of mRNA targets.GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.HPat provides a link between deadenylation and decapping in metazoa.4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation.The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patientsEvolution of eIF4E-Interacting ProteinsA conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complexDetailed molecular characterization of cord blood-derived endothelial progenitorsHELZ directly interacts with CCR4-NOT and causes decay of bound mRNAsStructural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeastA low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decayDirect role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repressionMolecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression4E-T-bound mRNAs are stored in a silenced and deadenylated form
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description
researcher ORCID ID = 0000-0003-3563-1788
@en
name
Cátia Igreja
@ast
Cátia Igreja
@en
Cátia Igreja
@nl
type
label
Cátia Igreja
@ast
Cátia Igreja
@en
Cátia Igreja
@nl
prefLabel
Cátia Igreja
@ast
Cátia Igreja
@en
Cátia Igreja
@nl
P21
P31
P496
0000-0003-3563-1788