Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

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The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function.

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P2860

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

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2016 nî lūn-bûn

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Discovery and Optimization of ...... Treatment of Type 2 Diabetes.

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Discovery and Optimization of ...... Treatment of Type 2 Diabetes.

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Discovery and Optimization of ...... Treatment of Type 2 Diabetes.

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Discovery and Optimization of ...... Treatment of Type 2 Diabetes.

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Andrew D Howard

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Birgit T Priest

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Christopher J Sinz

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Dann L Parker

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Derun Li

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Edward C Sherer

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Feroze Ujjainwalla

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George J Eiermann

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Gino Salituro

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Jenna Terebetski

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Diagnosis and classification of diabetes mellitus

Method for the isolation of intact islets of Langerhans from the rat pancreas

Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure.

Diabetes mellitus: pathogenesis and treatment strategies.

Dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

When poor solubility becomes an issue: from early stage to proof of concept.

Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

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1107-1111

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10.1021/ACSMEDCHEMLETT.6B00314

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27994747

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type-2 diabetes

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5150677

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

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P2860

P2860

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

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