Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development

Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development

Item
http://www.wikidata.org/entity/Q28504867
The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.Discovery and pharmacological effects of a novel GPR142 antagonist.High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139Identifying ligands at orphan GPCRs: current status using structure-based approaches.Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development.The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity.An association and haplotype analysis of porcine maternal infanticide: a model for human puerperal psychosis?Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.Differential role of GPR142 in tryptophan-mediated enhancement of insulin secretion in obese and lean mice.Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.
P2860

Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development

Item
http://www.wikidata.org/entity/Q28504867
description
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Dezember 2005 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/03/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/03/01)
@nl
наукова стаття, опублікована в березні 2006
@uk
مقالة علمية (نشرت في مارس 2006)
@ar
name
Characterisation and different ...... e and during mouse development
@ast
Characterisation and different ...... e and during mouse development
@en
Characterisation and different ...... e and during mouse development
@nl
type
label
Characterisation and different ...... e and during mouse development
@ast
Characterisation and different ...... e and during mouse development
@en
Characterisation and different ...... e and during mouse development
@nl
prefLabel
Characterisation and different ...... e and during mouse development
@ast
Characterisation and different ...... e and during mouse development
@en
Characterisation and different ...... e and during mouse development
@nl
P1433
P1476
P2093
P304
P31
P3181
P356
P433
P478
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P577
P698
P921
P3181
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P1433
P1476
Characterisation and different ...... e and during mouse development
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P2093
P304
P31
P3181
P356
10.1016/J.NEUROPHARM.2005.11.003
P433
P478
P50
P577
P698
P921