Stage-specific control of early B cell development by the transcription factor Ikaros.
about
ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid MalignanciesPrediction and validation of protein-protein interactors from genome-wide DNA-binding data using a knowledge-based machine-learning approachA Pipeline for Drug Target Identification and ValidationJanus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function.The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis.Computational Modeling of a Transcriptional Switch Underlying B-Lymphocyte Lineage Commitment of Hematopoietic Multipotent Cells.Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.Long Noncoding RNA Expression during Human B-Cell DevelopmentConstraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification.Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros.Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.Ikaros Is a Negative Regulator of B1 Cell Development and Function.Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survivalCXCL3 contributes to CD133(+) CSCs maintenance and forms a positive feedback regulation loop with CD133 in HCC via Erk1/2 phosphorylation.Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.YY1 plays an essential role at all stages of B-cell differentiation.DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cellsTissue-specific DNA demethylation is required for proper B-cell differentiation and function.Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2.PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia.Ikaros fingers on lymphocyte differentiation.The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 functionIRF4 and IRF8: Governing the virtues of B Lymphocytes.Genomics in acute lymphoblastic leukaemia: insights and treatment implications.Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome.PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development.Hematopoietic stem and progenitor cells as novel prognostic biomarkers of longevity in a murine model for amyotrophic lateral sclerosis.IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses.
P2860
Q26770729-0150E3B1-2AF7-4EF0-B5ED-C01430D01A7DQ31133691-EF8907B5-559E-4E32-ABBA-2F556ECCC081Q33793854-8DEB3FED-1BCE-4055-8912-F745CB9D5937Q35126258-D479CEC5-30A3-4EE5-8A49-66E86707E253Q35282150-D76794B0-601F-48A2-B880-30C06F18AA76Q35488884-B04A7F74-1BC5-426A-9ACD-E45C4949C64FQ35689414-CB135A90-84DA-44E1-8554-BF6FB719C490Q35723998-327BE07E-BD0B-4035-9013-E9F19DD4C180Q35761576-92DCD87C-B8E7-45F3-8593-5D6AB6B1AF6CQ35783785-19D767F3-3DFA-43C8-B4B5-9056A67EE307Q35928105-346CC784-F4B5-4ED9-A4EE-0FAA11F686B0Q36070422-BBB4548B-3C42-4716-9939-4761E8982481Q36088715-72C4A4A4-1077-4739-BE53-7D3646FE57FEQ36143247-6BA02364-85F6-4052-99C8-6382CF34CD0EQ36341356-453335E7-87B6-4018-A4F0-2972F2C0C85FQ36693283-2CE2AA59-432D-43C1-AB87-D6DD2F5F4C76Q36837426-13EE5CEA-A3A8-41FE-8F2E-133F19D19F15Q36884809-E81C9695-F591-4090-98C1-F1D0C4FC2F5DQ36931139-823D14E2-C6A3-487E-B8BD-556B9DE3D4AEQ36964853-5855882D-EE72-4B31-AF62-C5D3E5960C40Q36980511-3AA02D91-F78A-4C68-8DE6-77D93F5BF8B7Q37086666-B3603D27-5BF3-4362-8956-70441DF38D09Q37117574-37DBBBB7-259E-4ED0-A4BD-2A6265D97A34Q37173112-5E4617E4-5F5D-4BD2-8CA8-8078A9C0DD0FQ37343021-BFDEF111-CFF9-4E64-9521-6720ADCA35D2Q37415191-1FD3E9D3-718B-4213-A927-22E5DFC9C352Q37416655-C7D94C8D-DFDE-4BCE-84BA-CBE5426712E2Q37507603-81B5F94E-C1DA-4F18-87CB-A1D513E0F283Q37522927-1B26F2DA-A7DC-4E60-9BC8-E3B7C4BCDFA6Q37528135-B5EAA6FC-7842-41F5-8717-F616D3B2EA7DQ37662338-98A42F00-C425-44EB-868E-64AD92AE09CBQ38236141-0EFB543E-A100-4825-ACC8-B860D2C8F4EEQ38239865-AF115472-4659-45B1-918F-F550E589450DQ38288293-79298C93-5604-4DA3-AD91-37B84FF66D96Q38381463-B81D17FC-6F2D-4DDE-80B5-0D6EA8D00011Q38716760-60C6435F-1157-4AD0-92A8-FBFF2CC0FA9AQ38716763-A93F005D-D0AA-4D5E-9DED-1EBBA65A4C4DQ38722578-B4365978-52C1-444A-BEF7-01D1D5C12977Q38816820-B700CE26-42EE-4EF0-BCCA-81BDAC3E06F6Q38853131-44FDEF1A-85C7-428A-8375-6A256D7AD181
P2860
Stage-specific control of early B cell development by the transcription factor Ikaros.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh-hant
name
Stage-specific control of early B cell development by the transcription factor Ikaros.
@en
Stage-specific control of early B cell development by the transcription factor Ikaros.
@nl
type
label
Stage-specific control of early B cell development by the transcription factor Ikaros.
@en
Stage-specific control of early B cell development by the transcription factor Ikaros.
@nl
prefLabel
Stage-specific control of early B cell development by the transcription factor Ikaros.
@en
Stage-specific control of early B cell development by the transcription factor Ikaros.
@nl
P2093
P2860
P50
P356
P1433
P1476
Stage-specific control of early B cell development by the transcription factor Ikaros.
@en
P2093
Aleksandar Dakic
Anja Ebert
Barbara Werner
Elin Axelsson
Luisa Cimmino
Mareike Roth
Markus Jaritz
Martina Minnich
Sinan Gültekin
P2860
P304
P356
10.1038/NI.2828
P407
P577
2014-02-09T00:00:00Z