about
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteinshigh kinase activity BRAF mutants:scaffold:MAP2K:MAPK complexRAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteinsRAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteinsp-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteinsactivated RAF:scaffold:MAP2K:MAPK complexWDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complexMutant RAS:p-RAF complexes bind MAP2Ks and MAPKsHigh kinase activity BRAF mutants bind MAP2Ks and MAPKsRAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKsRAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKsp-BRAF and RAF fusion dimers bind MAP2Ks and MAPKsMAP2Ks and MAPKs bind to the activated RAF complexWDR83:LAMTOR2:LAMTOR3 binds MAPK components
P527
Q50256202-D94E5D61-58A7-4084-B086-5F8D2D954E83Q50256223-AAD2A5EA-5994-43A2-BFC5-BAFA18BDDD4EQ50256240-B8675263-B336-4AA5-BEBF-4D8DEC243754Q50256250-5061C7C3-CD2F-47DB-897B-56B758C7015DQ50256271-2401353F-7755-4792-AD09-3B586A4B63DCQ50263685-54D322FD-DA2A-4179-AB2F-97C9BCC525A9Q50263701-D8ADE9B4-F47C-4315-AF5E-CB32A58AF22FQ50288914-C1BDEC8B-9B42-4B3E-94DD-04245E79BFE6Q50288920-1EA233CD-BF7D-4015-ACB7-A4598E8250C1Q50288933-B9590F4D-1AEB-47D8-BDE9-33033ABC2678Q50288942-CBD9582C-735E-4844-931D-6846939BCD69Q50288949-51C3ECB1-201F-47F7-AE15-91DC52C4D166Q50292933-61C1154A-0316-4F7A-8946-F7141B8FE032Q50292938-27E5982F-6FF8-4303-8365-3384FF1BC295
P527
description
Defined set from Reactome
@en
name
MAP2K homo/heterodimers
@en
type
label
MAP2K homo/heterodimers
@en
prefLabel
MAP2K homo/heterodimers
@en
P527
P31
P3937
R-HSA-5672716