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NUMB binds ITCH
NUMB binds ITCH
Item
http://www.wikidata.org/entity/Q50298948
Q50298948
about
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
P527
Q45318276-B7E28ED6-518B-4422-A723-71F88D8261AC
Q45318278-71006577-F80B-466E-BDC1-6EE60CC127CC
P527
NUMB binds ITCH
Item
http://www.wikidata.org/entity/Q50298948
description
An instance of the biological reaction NUMB binds ITCH in Homo sapiens
@en
biologisch proces
@nl
name
NUMB binds ITCH
@en
type
Item
label
NUMB binds ITCH
@en
prefLabel
NUMB binds ITCH
@en
P2860
Q50298948-A3F774A3-9345-4191-92BA-BDEC4AFD857B
Q50298948-CBBCB7F8-0B5D-4718-8C95-EBAE206C3EDD
P2888
Q50298948-5A5A9298-AC9A-4640-B613-EA261FEAD006
P31
Q50298948-4AAC779C-2D7F-4D98-B2CC-146B05EF161C
P361
Q50298948-D687A267-8688-4032-AC0A-B08511F3241F
P3937
Q50298948-4D90500A-9250-47CF-89C7-E6132EF036B3
P527
Q50298948-6E8B1AA1-D403-4007-A922-923596E0F596
Q50298948-87E73DDC-69DB-4ECA-8980-11E0038FE80F
Q50298948-F31AB33F-91E7-477F-B3CD-0B08E841CAF7
P703
Q50298948-D9E6E983-E446-4DEC-9FE1-36961272300A
P2860
Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
P2888
reactome:R-HSA-5610735
P31
biological process
P361
Degradation of GLI1 by the proteasome
P3937
R-HSA-5610735
http://www.w3.org/2001/XMLSchema#string
P527
Itchy E3 ubiquitin protein ligase
NUMB endocytic adaptor protein
NUMB:ITCH
P703
Homo sapiens