about
Ligand-receptor interactionsActivation of SMOGLI proteins bind promoters of Hh responsive genes to promote transcriptionSMURF1/2 bind PTCH1SMURF1/2 ubiquitinates PTCH1SMURF1/2 dissociates from ub-PTCH1PTCH is internalizedGPR161 is internalizedGLI:SUFU translocates to the ciliary tip in response to Hh signalingGLI:SUFU dissociatesULK3:SUFU dissociatesULK3 phosphorylates GLIGLI translocates to the nucleusGLI proteins are phosphorylatedGLI proteins bind CDC73phosphorylated GLI proteins bind SPOP:CUL3:RBX1SPOP:CUL3:RBX1 ubiquitinates GLI2;3GLI2;3 are degraded by the proteasomeNUMB:ITCH binds GLI1NUMB:ITCH ubiquitinates GLI1ub-GLI is degraded by the proteasome
P361
Q45318279-76A14C3B-F751-49E3-AD02-EF801DCF3E6FQ45318280-F8521617-7B06-41B6-97F4-3C2572A588ADQ45318281-743E55C1-DCF9-444E-A658-21544AB16149Q50298955-31CB8C70-A336-49DA-AAD0-8EF181E9818CQ50298956-ADBCBDDB-4674-49C0-98A0-52E203CB4369Q50298957-38012827-24F8-4B2E-9C30-AC23823190EAQ50298958-1687BD0C-CE68-4B8D-9D38-0DF3695F1757Q50298959-2F0611BD-2107-4D5F-8911-78D306D933C6Q50298969-317F16B0-BF35-49F4-A3B7-8121F3A92104Q50298970-EF287EF8-A73F-43B3-A691-2F369E169FE9Q50298972-5ABC3093-2098-44F6-9DC3-118BE014ACBDQ50298973-E32A39A2-4C3B-4C99-8DE2-90369044EF2EQ50298974-21D7C816-049D-485F-B82A-8F10A6939B8AQ50298975-ACFAEA6E-7EF2-4A35-AEEF-DFA26228159BQ50298976-BC867DA0-DB87-43AA-8298-CA8ED8051B49Q50298981-C071C768-BFF6-49C6-9046-0D329B59DFBDQ50298982-A4FDC7C8-EAB7-424E-B3E5-CE2621B25C22Q50298983-A76A73C1-5E5E-4C10-A570-D8A6ABE2FC22Q50298984-F0AE8875-5D0B-496D-A7E8-2A62FC72B4F1Q50298985-B00D704C-7FF8-405A-99F8-A8DA8FC7EF51Q50298986-6C9A5A44-2889-4050-AC3B-AA1575F988F4
P361
description
An instance of the biological pathway Hedgehog 'on' state in Homo sapiens
@en
name
Hedgehog 'on' state
@en
type
label
Hedgehog 'on' state
@en
prefLabel
Hedgehog 'on' state
@en
P2860
P527
P2860
P3937
R-HSA-5632684