about
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakRNA association and nucleocytoplasmic shuttling by ataxin-1A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and BakStructural insights into the degradation of Mcl-1 induced by BH3 domainsA novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradationThe dendritic cell receptor Clec9A binds damaged cells via exposed actin filamentsApoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases.Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9How the Bcl-2 family of proteins interact to regulate apoptosis.HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stressAtaxin-7 can export from the nucleus via a conserved exportin-dependent signal.Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming.Subversion of the Bcl-2 life/death switch in cancer development and therapy.VDAC2 enables BAX to mediate apoptosis and limit tumor developmentMARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complexA small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Mark F van Delft
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Mark F van Delft
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Mark F van Delft
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Mark F van Delft
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Mark F van Delft
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type
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Mark F van Delft
@ast
Mark F van Delft
@en
Mark F van Delft
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Mark F van Delft
@nl
Mark F van Delft
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prefLabel
Mark F van Delft
@ast
Mark F van Delft
@en
Mark F van Delft
@es
Mark F van Delft
@nl
Mark F van Delft
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P106
P1153
6506884114
P21
P31
P496
0000-0002-3866-4318