Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit.
about
EAST syndrome: Clinical, pathophysiological, and genetic aspects of mutations in KCNJ10The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance.The role of an inwardly rectifying K(+) channel (Kir4.1) in the inner ear and hearing loss.Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1.Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants.Selective ablation of pillar and deiters' cells severely affects cochlear postnatal development and hearing in mice.Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of functionDefining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea.The Membrane Properties of Cochlear Root Cells are Consistent with Roles in Potassium Recirculation and Spatial Buffering.Generation and validation of a zebrafish model of EAST (epilepsy, ataxia, sensorineural deafness and tubulopathy) syndromeSmall-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10)Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome.A homozygous KCNJ10 mutation in Jack Russell Terriers and related breeds with spinocerebellar ataxia with myokymia, seizures, or both.Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Ablation of Kcnj10 expression in retinal explants revealed pivotal roles for Kcnj10 in the proliferation and development of Müller glia.Genetic defects in the hotspot of inwardly rectifying K(+) (Kir) channels and their metabolic consequences: a reviewHead bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.Spatial and temporal correlation in progressive degeneration of neurons and astrocytes in contusion-induced spinal cord injuryChemoconvulsant-induced seizure susceptibility: toward a common genetic basis?Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10.The expression, regulation, and function of Kir4.1 (Kcnj10) in the mammalian kidney.Molecular bases of K(+) secretory cells in the inner ear: shared and distinct features between birds and mammalsThe salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel.Aquaporin-4 and epilepsy.The molecular basis of blood pressure variation.Variable loss of Kir4.1 channel function in SeSAME syndrome mutations.Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner EarFunctional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity.Zucker diabetic fatty rats, a model for type 2 diabetes, develop an inner ear dysfunction that can be attenuated by losartan treatment.Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.
P2860
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P2860
Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Time course of inner ear degen ...... 4.1 potassium channel subunit.
@en
Time course of inner ear degen ...... 4.1 potassium channel subunit.
@nl
type
label
Time course of inner ear degen ...... 4.1 potassium channel subunit.
@en
Time course of inner ear degen ...... 4.1 potassium channel subunit.
@nl
prefLabel
Time course of inner ear degen ...... 4.1 potassium channel subunit.
@en
Time course of inner ear degen ...... 4.1 potassium channel subunit.
@nl
P2093
P1433
P1476
Time course of inner ear degen ...... 4.1 potassium channel subunit.
@en
P2093
Chi-Sung Chiu
Clemens Neusch
Henry A Lester
Nora Rozengurt
P356
10.1016/S0378-5955(02)00799-2
P577
2003-03-01T00:00:00Z