The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.
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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channelA recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsThe S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation GatingThe role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel.Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disordersMutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channelDouble mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel.Conservation analysis of residues in the S4-S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling.C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation.Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Coupling of voltage-sensors to the channel pore: a comparative viewStructural changes during HCN channel gating defined by high affinity metal bridges.Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.Identification of functionally critical residues in the channel domain of inositol trisphosphate receptorsAllosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel.Structural determinants of skeletal muscle ryanodine receptor gatinghERG gating microdomains defined by S6 mutagenesis and molecular modeling.Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of kv4.2 channelsHydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation.Aromatic-aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process.Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.Cytoplasmic domains and voltage-dependent potassium channel gating.HERG potassium channel regulation by the N-terminal eag domain.Voltage-dependent gating of HERG potassium channels.Mechanism of electromechanical coupling in voltage-gated potassium channels.Being flexible: the voltage-controllable activation gate of kv channels.Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.Molecular Pathophysiology of Congenital Long QT Syndrome.
P2860
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P2860
The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
@zh-hans
2006年学术文章
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2006年学术文章
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name
The S4-S5 linker directly coup ...... elated gene (hERG) K+ channel.
@en
The S4-S5 linker directly coup ...... an ether-a'-go-go-related gene
@nl
type
label
The S4-S5 linker directly coup ...... elated gene (hERG) K+ channel.
@en
The S4-S5 linker directly coup ...... an ether-a'-go-go-related gene
@nl
prefLabel
The S4-S5 linker directly coup ...... elated gene (hERG) K+ channel.
@en
The S4-S5 linker directly coup ...... an ether-a'-go-go-related gene
@nl
P2093
P2860
P356
P1476
The S4-S5 linker directly coup ...... elated gene (hERG) K+ channel.
@en
P2093
David R Piper
Jason Rupp
Martin Tristani-Firouzi
Tania Ferrer
P2860
P304
12858-12864
P356
10.1074/JBC.M513518200
P407
P577
2006-03-08T00:00:00Z