Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
about
Lipopolysaccharide hyperpolarizes guinea pig airway epithelium by increasing the activities of the epithelial Na+ channel and the Na+ - K+ pumpMutations in SPINT2 cause a syndromic form of congenital sodium diarrheaThe Epithelial Sodium Channel and the Processes of Wound HealingCPT-cGMP Is A New Ligand of Epithelial Sodium ChannelsEpithelial Na(+) channel regulation by cytoplasmic and extracellular factorsRegulation of αENaC transcriptionA long isoform of the epithelial sodium channel alpha subunit forms a highly active channelEpithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseasesIdentification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesisConserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition responseExpression and purification of the alpha subunit of the epithelial sodium channel, ENaC.Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases.A segment of gamma ENaC mediates elastase activation of Na+ transportCysteine palmitoylation of the γ subunit has a dominant role in modulating activity of the epithelial sodium channelInhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines.New role for plasmin in sodium homeostasis.Extracellular allosteric regulatory subdomain within the gamma subunit of the epithelial Na+ channel.Role of epithelial sodium channels and their regulators in hypertension.Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channelDefining an inhibitory domain in the gamma subunit of the epithelial sodium channelProteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second proteaseNa+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleftBase of the thumb domain modulates epithelial sodium channel gating.Second transmembrane domain modulates epithelial sodium channel gating in response to shear stressExternal Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains.ENaC structure and function in the wake of a resolved structure of a family member.Sodium retention and volume expansion in nephrotic syndrome: implications for hypertension.TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channelsPendrin gene ablation alters ENaC subcellular distribution and open probabilityExtracellular finger domain modulates the response of the epithelial sodium channel to shear stressFunctional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.Tissue kallikrein activation of the epithelial Na channelAcute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site.Probing the structural basis of Zn2+ regulation of the epithelial Na+ channel.Role of epithelial sodium channels in the regulation of lung fluid homeostasisRegulation of transport in the connecting tubule and cortical collecting duct
P2860
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P2860
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
@en
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
@nl
type
label
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
@en
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
@nl
prefLabel
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
@en
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
@nl
P2093
P2860
P1476
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
@en
P2093
James B Bruns
Marcelo D Carattino
Rebecca P Hughey
Thomas R Kleyman
P2860
P304
P356
10.1152/AJPRENAL.00439.2005
P50
P577
2006-01-31T00:00:00Z