about
Inhibition of HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates zinc ions from retroviral nucleocapsid zinc fingersRole of PFKFB3-driven glycolysis in vessel sproutingAutomatic and quantitative measurement of protein-protein colocalization in live cells.Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.The stem cell growth factor receptor KIT is not expressed on interstitial cells in bladderKinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivoAn intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions.A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export.The nucleotide analog cidofovir suppresses basic fibroblast growth factor (FGF2) expression and signaling and induces apoptosis in FGF2-overexpressing endothelial cells.Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein RevMeasuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer.Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus.Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors.Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma.The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin AXPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.HIV-1 Rev multimerization: mechanism and insights.Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays.Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement.Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors.L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents.Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells.Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action.Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs.A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase.Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors.Identification of different phenotypes of interstitial cells in the upper and deep lamina propria of the human bladder dome.Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1.CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin.A time-of-drug addition approach to target identification of antiviral compounds.Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides.Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives.
P50
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P50
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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Dirk Daelemans
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P106
P21
P31
P496
0000-0001-7092-1153