Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.
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Hedgehog signaling: modulation of cancer properies and tumor mircroenvironmentTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsNon-Canonical Hh Signaling in Cancer-Current Understanding and Future DirectionsAnti-cancer stem cell activity of a hedgehog inhibitor GANT61 in estrogen receptor-positive breast cancer cells.Blocking signaling at the level of GLI regulates downstream gene expression and inhibits proliferation of canine osteosarcoma cellsMitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signalingInhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cellsHIF-1α contributes to proliferation and invasiveness of neuroblastoma cells via SHH signaling.SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines.A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastomaTargeting the Hedgehog signaling pathway in cancer: beyond Smoothened.RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signalingAutocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway.In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.Ovarian and breast cancer spheres are similar in transcriptomic features and sensitive to fenretinide.Sonic hedgehog pathway contributes to gastric cancer cell growth and proliferation.Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cellsTargeted treatment for sonic hedgehog-dependent medulloblastoma.INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastomaEvolving molecular era of childhood medulloblastoma: time to revisit therapy.Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosisBasal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.Improved therapy for neuroblastoma using a combination approach: superior efficacy with vismodegib and topotecanExpression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain.Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer.Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis.The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK.Hedgehog signalling pathway inhibitors as cancer suppressing agentsRole of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
P2860
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P2860
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Targeting the hedgehog signal ...... l growth in vitro and in vivo.
@en
Targeting the hedgehog signal ...... l growth in vitro and in vivo.
@nl
type
label
Targeting the hedgehog signal ...... l growth in vitro and in vivo.
@en
Targeting the hedgehog signal ...... l growth in vitro and in vivo.
@nl
prefLabel
Targeting the hedgehog signal ...... l growth in vitro and in vivo.
@en
Targeting the hedgehog signal ...... l growth in vitro and in vivo.
@nl
P2093
P2860
P50
P356
P1476
Targeting the hedgehog signal ...... l growth in vitro and in vivo.
@en
P2093
Cecilia Dyberg
Jelena Milosevic
John I Johnsen
Ole M Fuskevåg
Takashi Shimokawa
P2860
P304
P356
10.1002/IJC.27820
P577
2012-10-03T00:00:00Z