about
Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT-Part I: Program Implementation and Lessons LearnedInduction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit elementSingle cell analysis of switch-like induction of CYP1A1 in liver cell linesIdentification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazineRegional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane.The next generation of risk assessment multiyear study - highlights of findings, applications to risk assessment, and future directionsMolecular signaling network motifs provide a mechanistic basis for cellular threshold responsesToxicity testing in the 21st century: a vision and a strategyCNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretionAdaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety AssessmentUpdate on a Pharmacokinetic-Centric Alternative Tier II Program for MMT-Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk AssessmentPhase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responsesDose response relationship in anti-stress gene regulatory networksToxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathwaysDeveloping tools for defining and establishing pathways of toxicityThe Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortiumt4 workshop report: Pathways of ToxicityEditor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of AdipogenesisEditor's Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety AssessmentInhaled carbon nanotubes reach the subpleural tissue in miceUltrasensitive response motifs: basic amplifiers in molecular signalling networks.Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.The use of quantitative histological and molecular data for risk assessment and biologically based model development.Kinetic and mechanistic data needs for a human phsiologically based pharmacokinetic (PBPK) model for acrylamide: pharmacokinetic model for acrylamide.Application of pharmacokinetic data to the risk assessment of inhaled manganese.A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure.Quantitative interpretation of human biomonitoring data.Reactive oxygen species as a signal in glucose-stimulated insulin secretion.Development of an immunochemical detection method for atrazine-induced albumin adducts.Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin.Biological regulation of receptor-hormone complex concentrations in relation to dose-response assessments for endocrine-active compounds.A systems biology perspective on Nrf2-mediated antioxidant responseROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin.A deterministic map of Waddington's epigenetic landscape for cell fate specification.Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.A framework for the next generation of risk science.Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.
P50
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P50
description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Melvin E Andersen
@nl
Melvin E Andersen
@sl
Melvin E. Andersen
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Melvin E. Andersen
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type
label
Melvin E Andersen
@nl
Melvin E Andersen
@sl
Melvin E. Andersen
@en
Melvin E. Andersen
@es
prefLabel
Melvin E Andersen
@nl
Melvin E Andersen
@sl
Melvin E. Andersen
@en
Melvin E. Andersen
@es
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0000 0003 8598 4143
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no2004119381
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lccn-no2004119381