Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis. - Wikidata - wikimedia - TriplyDB

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

http://www.wikidata.org/entity/Q51061806

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Pancreatic Cancer Genetics Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin Epidemiology and Inherited Predisposition for Sporadic Pancreatic Adenocarcinoma Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis Regulation of Cellular Identity in Cancer The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21 The secret origins and surprising fates of pancreas tumors Nuclear receptors and pathogenesis of pancreatic cancer.Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A.miR-186 and 326 predict the prognosis of pancreatic ductal adenocarcinoma and affect the proliferation and migration of cancer cells Integrative analysis of haplotype-resolved epigenomes across human tissues.The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese.BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis.Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation.Beyond GWASs: illuminating the dark road from association to function A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm).PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.Pathogenesis of pancreatic cancer: lessons from animal models.Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial-mesenchymal transition (EMT) markers.The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.Acinar cell plasticity and development of pancreatic ductal adenocarcinoma.Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.Differentiation and Inflammation: 'Best Enemies' in Gastrointestinal Carcinogenesis.Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.Inherited pancreatic cancer.Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.Association between NR5A2 and the risk of pancreatic cancer, especially among Caucasians: a meta-analysis of case-control studies.Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment.Arid1a restrains Kras-dependent changes in acinar cell identity.

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Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

http://www.wikidata.org/entity/Q51061806

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

@yue

2013年學術文章

@zh-hant

name

Nr5a2 heterozygosity sensitise ...... ven pancreatic tumourigenesis.

@en

Nr5a2 heterozygosity sensitise ...... ven pancreatic tumourigenesis.

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type

label

Nr5a2 heterozygosity sensitise ...... ven pancreatic tumourigenesis.

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Nr5a2 heterozygosity sensitise ...... ven pancreatic tumourigenesis.

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prefLabel

Nr5a2 heterozygosity sensitise ...... ven pancreatic tumourigenesis.

@en

Nr5a2 heterozygosity sensitise ...... ven pancreatic tumourigenesis.

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GUTJNL-2012-304381

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Nr5a2 heterozygosity sensitise ...... iven pancreatic tumourigenesis

@en

P2093

Antonio Salas

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Francisco X Real

http://www.w3.org/2001/XMLSchema#string

Kristina Schoonjans

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Marta Cañamero

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Natalia del Pozo

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P2860

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage

The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element

RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras.

Liver receptor homolog 1 controls the expression of carboxyl ester lipase.

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647-655

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10.1136/GUTJNL-2012-304381

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4

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Jaroslaw Cendrowski

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2013-04-18T00:00:00Z

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23598351

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