Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. - Wikidata - wikimedia - TriplyDB

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

http://www.wikidata.org/entity/Q51504024

about

Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors Genetically engineered ERα-positive breast cancer mouse models.PIK3CA expression in diffuse large B cell lymphoma tissue and the effect of its knockdown in vitro.Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.Genetically engineered mouse models of PI3K signaling in breast cancer.Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences.Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy.Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types Elevated PI3K signaling drives multiple breast cancer subtypes.An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet.PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development Somatic PIK3CA mutations as a driver of sporadic venous malformations.A Tumor initiating cell-enriched prognostic signature for HER2+:ERα- breast cancer; rationale, new features, controversies and future directions The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas.Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R.A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer.Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors.Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment.Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation.Frequent PIK3CA activating mutations in nipple adenomas.Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors.MDM2 Amplification and PI3KCA Mutation in a Case of Sclerosing Rhabdomyosarcoma Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation.Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations.

P2860

Q24608709-6213519F-A3A6-4C3C-9448-9B4B64437CD1 Q24632718-A581B157-374B-4EC8-9B59-A1BAD349FEB1 Q26766039-8ABADA68-1F23-4198-9B7C-0A286F6C8CC9 Q27675831-7C0BE729-0333-43B4-BB5B-CA1729BE9D8E Q28247338-A6E9166F-CEA9-4228-8828-518CD11CDB99 Q28729079-5E849F05-757B-4182-9271-38B1CC103398 Q33578641-206DEB30-095E-40A8-BB78-757587A54250 Q33602560-E5531FCE-0D86-4974-A41A-57480D358A26 Q33742688-A01706E4-6714-48B4-ABCD-104F1B9B6D12 Q33761491-1746E975-845D-4F3B-AB28-D3FE5C113897 Q34229795-D054EDEC-166B-4B5E-BFF3-5DF8AA6FF0F8 Q34332175-A1320055-CD3A-4C45-81C0-15CAA5E55143 Q34654793-C30FD36B-CF41-4ACF-AEA1-E420CE9CA341 Q35020412-13EA5BA3-7DD1-4369-AE2B-788DF679A327 Q35020913-FB7547C0-320A-4206-980C-A2728704E21F Q35215580-C33BA857-EB19-4E0E-AB2F-227B6E51DA23 Q35640263-A884A9D9-B284-47C8-B93C-F0115A97AC01 Q35698954-3762F415-FBB7-4E68-A6AB-B8D04419BA54 Q35919716-EDCDB62C-2E0F-4122-ACA8-3DF77410E467 Q36242891-297C57B9-CEF3-4937-88E8-90F2A8091B16 Q36245945-DA933722-B6A8-4069-9ABE-8505EE5B5D47 Q36549790-1FAB722E-AF74-479B-92BC-A7533AFAF033 Q37114126-9FA273DD-A4D3-4023-9F92-05E3B6F7687A Q37130685-BEA57086-6065-466A-AC67-6F4F09AD9474 Q37207675-7D534B6A-1468-48F7-9C44-86F90F864311 Q37228078-93F101A5-F328-4BB2-A717-F8E9D7682DB9 Q37275769-7F3E1904-B9AF-4456-B4FD-8ED80E304F21 Q37287482-366CD131-8C81-4638-9B50-3820BED092B2 Q37349731-BF066BFD-2BC1-4DE3-9C9B-C4694DEFD017 Q37479076-64539B8F-3462-43B9-AB10-F720A9E02AE2 Q38079299-32B6DD49-E766-4FCC-8CBB-A67F700689A5 Q38974959-38F018B2-3DE3-4A19-AA68-557D056F3FC3 Q39023175-C777C7BF-992E-4588-BBC7-18F7DF329C78 Q39355041-06EDD925-1CDB-4BD3-A624-279FA55116F7 Q39577466-62F02F09-ED09-476C-9D9B-2BBF02D43F4A Q41127927-6BBBBCC2-07F7-4B68-B68D-51EDF0ADEEFD Q41563962-CD2A7AC8-56AB-4BE2-A71F-DFAE3AB03740 Q42573787-CB8B81CB-D72F-44E6-BB48-8227C08691CE Q47111476-0091FE07-F9C9-4E9C-BA39-5DAB6B269683 Q48204602-541DC055-415F-4418-980A-EBE0D3149E91

P2860

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

http://www.wikidata.org/entity/Q51504024

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

@zh-hant

name

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

@en

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

@nl

type

label

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

@en

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

@nl

prefLabel

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

@en

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

@nl

P1433

Q51504024-CCEF679F-9953-4CAE-A958-9B4C1F285EB7

P1476

Q51504024-0DBC49E2-93B7-43B3-AD1C-238D252DCCB3

P2093

Q51504024-12422905-521C-4DD4-BB25-A0FEA178A21A

Q51504024-390D60A8-2A14-4635-A04D-3FB850CDE68A

Q51504024-6ADAD9A0-38EA-46D4-853E-660214446BC3

Q51504024-79964453-6DE4-4B93-A021-8B0368F51387

Q51504024-8223EE74-6726-449A-99F9-FB363FF6B7F3

Q51504024-822BDF8B-82D2-4F6B-BA6F-4C82BBAC8B8A

Q51504024-8898FC65-FB60-433F-B85A-4418096457D2

Q51504024-B27ECD04-5511-4B05-B887-6E301C104BD3

Q51504024-C27A3288-AD28-4EAF-8EC1-44FED5D0C644

Q51504024-C36DC6A1-DC55-4936-B613-4A5F6C4E59A6

P304

Q51504024-7C0C9EFD-A5F1-4AD1-B3F4-DC4A0170D261

P31

Q51504024-2AF96B88-BCB5-4CDD-8D58-E0347C58C77A

P356

Q51504024-865933FB-4F22-4164-B03B-0C8083EAD9DE

P407

Q51504024-C74D24D4-7E2E-4D2D-A2B9-C9BD31832862

P433

Q51504024-2F124799-E1F3-4A7D-B428-D2FBE3F281B1

P478

Q51504024-CA88F9A7-AC1F-4E99-A4E8-71EDEAABAF8C

P577

Q51504024-179EC81B-27E5-4A40-8E52-DAB0C0B8E5FE

P698

Q51504024-C73DB812-2C07-4B98-9821-DBC136843A79

P356

0008-5472.CAN-10-0738

P1433

Cancer Research

P1476

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

@en

P2093

Amanda J Loch

http://www.w3.org/2001/XMLSchema#string

Eldad Zacksenhaus

http://www.w3.org/2001/XMLSchema#string

Jeff C Liu

http://www.w3.org/2001/XMLSchema#string

Jessica R Adams

http://www.w3.org/2001/XMLSchema#string

Katherine L Wright

http://www.w3.org/2001/XMLSchema#string

Keli Xu

http://www.w3.org/2001/XMLSchema#string

Natalia M Ruiz Agamez

http://www.w3.org/2001/XMLSchema#string

Ruth G Wong

http://www.w3.org/2001/XMLSchema#string

Sean E Egan

http://www.w3.org/2001/XMLSchema#string

Timothy F Lane

http://www.w3.org/2001/XMLSchema#string

P304

2706-2717

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/0008-5472.CAN-10-0738

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

71

http://www.w3.org/2001/XMLSchema#string

P577

2011-02-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21324922

http://www.w3.org/2001/XMLSchema#string