about
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblastsMitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cellsThe insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growthMystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growthIGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy ResistanceInduction of apoptosis by the Bcl-2 homologue BakDefects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signallingBile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell modelsSite-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein levelIdentification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells.Regulation of IGF-I receptor signaling in tumor cells.Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcriptionIdentification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosisSerine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growthPDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis.RACK1 to the future--a historical perspectiveRibosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome.Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB.Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin.Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L).EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion.RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells.Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.Rethinking the bile acid/gut microbiome axis in cancer.PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction.RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells.HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion.A cell viability assay based on monitoring respiration by optical oxygen sensingThe insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Rosemary O'Connor
@ast
Rosemary O'Connor
@en
Rosemary O'Connor
@es
Rosemary O'Connor
@nl
Rosemary O'Connor
@sl
type
label
Rosemary O'Connor
@ast
Rosemary O'Connor
@en
Rosemary O'Connor
@es
Rosemary O'Connor
@nl
Rosemary O'Connor
@sl
prefLabel
Rosemary O'Connor
@ast
Rosemary O'Connor
@en
Rosemary O'Connor
@es
Rosemary O'Connor
@nl
Rosemary O'Connor
@sl
P1053
B-7902-2014
P106
P31
P3829
P496
0000-0002-0687-3422