Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration. - Wikidata - wikimedia - TriplyDB

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.

http://www.wikidata.org/entity/Q39970150

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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance Structure of human Rack1 protein at a resolution of 2.45 Å PP2A: The Wolf in Sheep's Clothing?Promoting cell proliferation using water dispersible germanium nanowires RACK1, A multifaceted scaffolding protein: Structure and function.Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma.Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner RACK1 predicts poor prognosis and regulates progression of esophageal squamous cell carcinoma through its epithelial-mesenchymal transition.CLCA splicing isoform associated with adhesion through β1-integrin and its scaffolding protein: specific expression in undifferentiated epithelial cells Protein phosphorylation during Plasmodium berghei gametogenesis.The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis.Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans.Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK)RACK1 Function in Cell Motility and Protein Synthesis.PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.RACK1 modulates NF-κB activation by interfering with the interaction between TRAF2 and the IKK complex.Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology.RACK1, a versatile hub in cancer.The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1.Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells.Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis.Patterns of structural dynamics in RACK1 protein retained throughout evolution: a hydrogen-deuterium exchange study of three orthologs.RACK1 to the future--a historical perspective Phosphorylation status of nuclear ribosomal protein S3 is reciprocally regulated by protein kinase C{delta} and protein phosphatase 2A.Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.In vivo RNAi screen identifies candidate signaling genes required for collective cell migration in Drosophila ovary.RACK1 is involved in endothelial barrier regulation via its two novel interacting partners The Dictyostelium discoideum RACK1 orthologue has roles in growth and development.Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors.Long-term exposure to carcinoma-associated fibroblasts makes breast cancer cells addictive to integrin β1.

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Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.

http://www.wikidata.org/entity/Q39970150

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Tyrosine 302 in RACK1 is essen ...... l proliferation and migration.

@en

Tyrosine 302 in RACK1 is essen ...... l proliferation and migration.

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type

label

Tyrosine 302 in RACK1 is essen ...... l proliferation and migration.

@en

Tyrosine 302 in RACK1 is essen ...... l proliferation and migration.

@nl

prefLabel

Tyrosine 302 in RACK1 is essen ...... l proliferation and migration.

@en

Tyrosine 302 in RACK1 is essen ...... l proliferation and migration.

@nl

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Journal of Biological Chemistry

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Tyrosine 302 in RACK1 is essen ...... l proliferation and migration.

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P2093

George S Baillie

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Martin J Lynch

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Patrick A Kiely

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P2860

The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1

WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A

RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

Coordinated movement of RACK1 with activated betaIIPKC

Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits

Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

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10.1074/JBC.M800802200

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34

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283

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Miles D. Houslay

Rosemary O'Connor

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2008-06-19T00:00:00Z

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18567578

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