Pleiotropic scaling of gene effects and the 'cost of complexity'.
about
Compensatory evolution and the origins of innovationsFactors influencing the effect size distribution of adaptive substitutionsIntegrated phenotypes: understanding trait covariation in plants and animalsMendelian randomization: genetic anchors for causal inference in epidemiological studiesMosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrainThe effect of dietary adaption on cranial morphological integration in capuchins (order Primates, genus Cebus)The genetic architecture of novel trophic specialists: larger effect sizes are associated with exceptional oral jaw diversification in a pupfish adaptive radiation.The genetic architecture of local adaptation and reproductive isolation in sympatry within the Mimulus guttatus species complex.Non-contact measurement of linear external dimensions of the mouse eye.Aggressive behaviours, food deprivation and the foraging gene.The emergence of complexity and restricted pleiotropy in adapting networks.Understanding and using quantitative genetic variationThe impact of multifunctional genes on "guilt by association" analysisPleiotropic mutations are subject to strong stabilizing selection.Genome factor and gene pleiotropy hypotheses in protein evolution.A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae.Genomic patterns of pleiotropy and the evolution of complexityOne hundred years of pleiotropy: a retrospectiveFitness recovery and compensatory evolution in natural mutant lines of C. elegans.The many faces of pleiotropy.Linear motif-mediated interactions have contributed to the evolution of modularity in complex protein interaction networksCanonical correlation analysis for gene-based pleiotropy discoveryImproved drug therapy: triangulating phenomics with genomics and metabolomics.The genesis of an exceptionally lethal venom in the timber rattlesnake (Crotalus horridus) revealed through comparative venom-gland transcriptomics.Fisher's geometric model with a moving optimum.Informed consent in genomics and genetic research.Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology.Dissection of complex adult traits in a mouse synthetic population.The Genetic Architecture of Domestication in AnimalsSynergistic Pleiotropy Overrides the Costs of Complexity in Viral Adaptation.Gene functional trade-offs and the evolution of pleiotropy.QTL clustering as a mechanism for rapid multi-trait evolutionDissecting the pleiotropic consequences of a quantitative trait nucleotide.Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross lineThe nature and extent of mutational pleiotropy in gene expression of male Drosophila serrata.The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.Epigenetic resolution of the 'curse of complexity' in adaptive evolution of complex traits.The distribution of genetic variance across phenotypic space and the response to selection.The Utility of Fisher's Geometric Model in Evolutionary Genetics.Genotypic Complexity of Fisher's Geometric Model.
P2860
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P2860
Pleiotropic scaling of gene effects and the 'cost of complexity'.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Pleiotropic scaling of gene effects and the 'cost of complexity'.
@en
Pleiotropic scaling of gene effects and the 'cost of complexity'.
@nl
type
label
Pleiotropic scaling of gene effects and the 'cost of complexity'.
@en
Pleiotropic scaling of gene effects and the 'cost of complexity'.
@nl
prefLabel
Pleiotropic scaling of gene effects and the 'cost of complexity'.
@en
Pleiotropic scaling of gene effects and the 'cost of complexity'.
@nl
P2093
P50
P356
P1433
P1476
Pleiotropic scaling of gene effects and the 'cost of complexity'
@en
P2093
David Waxman
James M Cheverud
Joel R Peck
P2860
P2888
P304
P356
10.1038/NATURE06756
P407
P577
2008-03-01T00:00:00Z
P5875
P6179
1044357623