Allosteric modulation of muscarinic acetylcholine receptors.
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Activation and allosteric modulation of a muscarinic acetylcholine receptorStructure of the human M2 muscarinic acetylcholine receptor bound to an antagonistNovel Allosteric Modulators of G Protein-coupled ReceptorsA new mechanism of allostery in a G protein-coupled receptor dimerTargeting glutamate synapses in schizophreniaThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsMolecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic propertiesMapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptorAccelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor.Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass spectrometryIdentification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling biasStructural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.A novel fast mechanism for GPCR-mediated signal transduction--control of neurotransmitter release.Crystal structures of the M1 and M4 muscarinic acetylcholine receptorsStructural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptorsImpact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor.Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activationAllosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryDistinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1).Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophreniaEmploying novel animal models in the design of clinically efficacious GPCR ligands.Muscarinic acetylcholine receptors: novel opportunities for drug development.Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.Allosteric Modulators of the Class A G Protein Coupled Receptors.A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation.Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor.Cholinergic currents in leg motoneurons of Carausius morosus.Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors.Pharmacological characterization of M1 muscarinic acetylcholine receptor-mediated Gq activation in rat cerebral cortical and hippocampal membranes.Gaussian Accelerated Molecular Dynamics in NAMD.Gaussian Accelerated Molecular Dynamics: Theory, Implementation, and Applications.
P2860
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P2860
Allosteric modulation of muscarinic acetylcholine receptors.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
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2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Allosteric modulation of muscarinic acetylcholine receptors.
@en
Allosteric modulation of muscarinic acetylcholine receptors.
@nl
type
label
Allosteric modulation of muscarinic acetylcholine receptors.
@en
Allosteric modulation of muscarinic acetylcholine receptors.
@nl
prefLabel
Allosteric modulation of muscarinic acetylcholine receptors.
@en
Allosteric modulation of muscarinic acetylcholine receptors.
@nl
P2860
P1476
Allosteric modulation of muscarinic acetylcholine receptors.
@en
P2093
Arthur Christopoulos
Karen J Gregory
P2860
P304
P356
10.2174/157015907781695946
P577
2007-09-01T00:00:00Z