Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

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Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年學術文章

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2018年學術文章

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Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

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Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

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Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

@en

Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

@nl

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Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

@en

Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.

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P1476

Long term rapamycin treatment improves mitochondrial DNA quality in aging mice

@en

P2093

Allen Herbst

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Jason Bielas

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Jessica Hui

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Judd M Aiken

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Kevin Widjaja

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Richard A Miller

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P2860

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Mitophagy plays a central role in mitochondrial ageing

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia.

Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

P304

125-131

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P31

scholarly article

P356

10.1016/J.EXGER.2018.02.021

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P478

106

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P50

Debbie McKenzie

Jonathan Wanagat

S V Brooks

P577

2018-02-24T00:00:00Z

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P698

29486228

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P921

mitochondrial DNA

P932

5911406

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