Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators.

Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators.

Item
http://www.wikidata.org/entity/Q51769725
Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel OpenerVoltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission.Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes.Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents.KCNQ2 encephalopathy: Features, mutational hot spots, and ezogabine treatment of 11 patients.Potassium channels in peripheral pain pathways: expression, function and therapeutic potential.M-currents (Kv7.2-7.3/KCNQ2-KCNQ3) Are Responsible for Dysfunctional Autonomic Control in Hypertensive Rats.Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors.M-type K(+) channels in peripheral nociceptive pathways.Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices.Drug target identification at the crossroad of neuronal apoptosis and survival.Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells.Kv7(KCNQ)-K+-Channels Influence Total Peripheral Resistance in Female but Not Male Rats, and Hamper Catecholamine Release in Hypertensive Rats of Both Sexes.Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation.
P2860

Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators.

Item
http://www.wikidata.org/entity/Q51769725
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Design, synthesis and biologic ...... potassium channel activators.
@en
Design, synthesis and biologic ...... potassium channel activators.
@nl
type
label
Design, synthesis and biologic ...... potassium channel activators.
@en
Design, synthesis and biologic ...... potassium channel activators.
@nl
prefLabel
Design, synthesis and biologic ...... potassium channel activators.
@en
Design, synthesis and biologic ...... potassium channel activators.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P577
P5875
P698
P356
P1433
P1476
Design, synthesis and biologic ...... potassium channel activators.
@en
P2093
P304
P31
P356
10.1016/J.EJMECH.2011.01.010
P433
P478
P577
P5875
P698