Protein kinase A type I and type II define distinct intracellular signaling compartments.
about
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardiumRadixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferationα-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titinThe genetically encoded tool set for investigating cAMP: more than the sum of its partsStudying GPCR/cAMP pharmacology from the perspective of cellular structureCaV1.2 signaling complexes in the heartPhosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotidesSpatial control of cAMP signalling in health and diseaseCompartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophyAlterations of cAMP-dependent signaling in dystrophic skeletal muscleCompartmentalization of β-adrenergic signals in cardiomyocytesThe role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulationsFRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cellsGraphical approach to model reduction for nonlinear biochemical networks.Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytescGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac MyocytesPKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signalingMechanisms of cyclic AMP compartmentation revealed by computational models.Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment.PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signallingDesign of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling.FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes.Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform.Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascadesParticipation of myosin Va and Pka type I in the regeneration of neuromuscular junctions.Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes.Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells.Both PKA and Epac pathways mediate N-acetylcysteine-induced Connexin43 preservation in rats with myocardial infarctionAKAPs: the architectural underpinnings of local cAMP signaling.Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems.CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts.Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.Hematopoietic neoplasms in Prkar2a-deficient miceAnchoring proteins as regulators of signaling pathways.PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.
P2860
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P2860
Protein kinase A type I and type II define distinct intracellular signaling compartments.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Protein kinase A type I and type II define distinct intracellular signaling compartments.
@en
Protein kinase A type I and type II define distinct intracellular signaling compartments.
@nl
type
label
Protein kinase A type I and type II define distinct intracellular signaling compartments.
@en
Protein kinase A type I and type II define distinct intracellular signaling compartments.
@nl
prefLabel
Protein kinase A type I and type II define distinct intracellular signaling compartments.
@en
Protein kinase A type I and type II define distinct intracellular signaling compartments.
@nl
P2093
P50
P1433
P1476
Protein kinase A type I and type II define distinct intracellular signaling compartments.
@en
P2093
Anna Terrin
Anna Zoccarato
George S Baillie
Valentina Lissandron
P304
P356
10.1161/CIRCRESAHA.108.174813
P577
2008-08-28T00:00:00Z