Ionworks HT: a new high-throughput electrophysiology measurement platform.
about
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.Fluorescence imaging of electrically stimulated cells.Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperatureProfiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.QPatch: the past, present and future of automated patch clamp.Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniquesVenom peptides as a rich source of cav2.2 channel blockers.Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.Pulmonary edema due to oral gavage in a toxicological study related to aquaporin-1, -4 and -5 expression.Turning up the pace of ion channel screening in drug discovery.An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing riskValue of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines.Sodium channel blockers for neuropathic pain.Ion channels as novel therapeutic targets in the treatment of pain.Screening technologies for ion channel drug discovery.Strategies for the real-time detection of Ca2+ channel events of single cells: recent advances and new possibilities.hERG subunit composition determines differential drug sensitivity.Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel.Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia.Novel methodology to identify TRPV1 antagonists independent of capsaicin activation.Symmetric kv1.5 blockers discovered by focused screening.Computational Models for Predictive Cardiac Ion Channel Pharmacology.A place for high-throughput electrophysiology in cardiac safety: screening hERG cell lines and novel compounds with the ion works HTTM system.Development of a novel automated ion channel recording method using "inside-out" whole-cell membranes.A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel.Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish heart.New strategies in ion channel screening for drug discovery: are there ways to improve its productivity?Use of escin as a perforating agent on the IonWorks quattro automated electrophysiology platform.Overview of Electrophysiological Techniques.Validation of a high-throughput, automated electrophysiology platform for the screening of nicotinic agonists and antagonists.Automated Patch Clamp Analysis of nAChα7 and Na(V)1.7 Channels.An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment.Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential.A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1.High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment.RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345.Renaissance of ion channel research and drug discovery by patch clamp automation.Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells.
P2860
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P2860
Ionworks HT: a new high-throughput electrophysiology measurement platform.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Ionworks HT: a new high-throughput electrophysiology measurement platform.
@en
Ionworks HT: a new high-throughput electrophysiology measurement platform.
@nl
type
label
Ionworks HT: a new high-throughput electrophysiology measurement platform.
@en
Ionworks HT: a new high-throughput electrophysiology measurement platform.
@nl
prefLabel
Ionworks HT: a new high-throughput electrophysiology measurement platform.
@en
Ionworks HT: a new high-throughput electrophysiology measurement platform.
@nl
P2093
P356
P1476
Ionworks HT: a new high-throughput electrophysiology measurement platform.
@en
P2093
Brad Neagle
Derek J Trezise
Jennings Worley
Kirk Schroeder
P356
10.1177/1087057102239667
P577
2003-02-01T00:00:00Z