Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation.
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The many faces of aire in central tolerancePost-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific AutoantigensFGFR2IIIb signaling regulates thymic epithelial differentiationAire and T cell developmentTranscriptional regulation by AIRE: molecular mechanisms of central toleranceThymic and Postthymic Regulation of Naïve CD4(+) T-Cell Lineage Fates in Humans and Mice ModelsInduction of central tolerance by the factor Aire: molecular and epigenetic regulationThymic epithelial cell development and differentiation: cellular and molecular regulationLymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patientsModulation of Aire regulates the expression of tissue-restricted antigensAire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-toleranceSmad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development.DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration.Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis.Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.Control of central and peripheral tolerance by Aire.Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesisAire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.Thymus-specific deletion of insulin induces autoimmune diabetes.Persistent degenerative changes in thymic organ function revealed by an inducible model of organ regrowth.Proliferative arrest and rapid turnover of thymic epithelial cells expressing AireAire promotes the self-renewal of embryonic stem cells through Lin28.Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism.Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiatedGenerating intrathymic microenvironments to establish T-cell tolerance.Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiationHuman APECED; a Sick Thymus Syndrome?Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell populationLymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.The thymus medulla slowly yields its secrets.Learning to be tolerant: how T cells keep out of trouble.AIRE in the thymus and beyond.Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla.Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications.Models of aire-dependent gene regulation for thymic negative selection.The ambiguity in immunology.TNF receptor family signaling in the development and functions of medullary thymic epithelial cells.Which model better fits the role of aire in the establishment of self-tolerance: the transcription model or the maturation model?Thymic stromal cell subsets for T cell development.
P2860
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P2860
Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Aire-dependent alterations in ...... ic epithelial differentiation.
@en
Aire-dependent alterations in ...... ic epithelial differentiation.
@nl
type
label
Aire-dependent alterations in ...... ic epithelial differentiation.
@en
Aire-dependent alterations in ...... ic epithelial differentiation.
@nl
prefLabel
Aire-dependent alterations in ...... ic epithelial differentiation.
@en
Aire-dependent alterations in ...... ic epithelial differentiation.
@nl
P2093
P1476
Aire-dependent alterations in ...... ic epithelial differentiation.
@en
P2093
Andrew G Farr
Geoffrey O Gillard
Leena Peltonen
Matthew Erickson
P304
P356
10.4049/JIMMUNOL.178.5.3007
P407
P50
P577
2007-03-01T00:00:00Z