about
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell deathPharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramineZebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plantsIntegration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural productsOptimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolitesA phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signalingInsights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsyDifferential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agentRadioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation.Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction.Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efflux.In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosinAn overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications.Structure-based identification of OATP1B1/3 inhibitors.Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin.Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.The multifaceted photocytotoxic profile of hypericin.Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage.Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder.Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models.Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removalElucidation of the tumoritropic principle of hypericin.Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts.Differential cytotoxic effects induced after photosensitization by hypericin.Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica NanoparticlesEvans blue-mediated white-light detection of non-muscle-invasive bladder cancer: A preclinical feasibility and safety study using a rat bladder urothelial cell carcinoma model.Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish.Continuing pursuit for ideal systemic anticancer radiotherapeutics.Inhibition of glutamate decarboxylase (GAD) by ethyl ketopentenoate (EKP) induces treatment-resistant epileptic seizures in zebrafish.Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.Biodistribution of Evans blue in an orthotopic AY-27 rat bladder urothelial cell carcinoma model: implication for the improved diagnosis of non-muscle-invasive bladder cancer (NMIBC) using dye-guided white-light cystoscopy.Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model.The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease.Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy.Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors.
P50
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P50
description
hulumtues
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onderzoeker
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հետազոտող
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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Peter de Witte
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P106
P1153
7006646483
P21
P31
P496
0000-0002-9989-9567