The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. - Wikidata - wikimedia - TriplyDB

The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.

The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.

http://www.wikidata.org/entity/Q52168068

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New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment Regulation of Cellular Identity in Cancer Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment Genetic and molecular abnormalities in tumors of the bone and soft tissues.A time- and dose-dependent STAT1 expression system.FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E.DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2.Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop.The TET family of proteins: functions and roles in disease.Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3 Animal models of soft-tissue sarcoma.The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells.Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics.mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.Advances in sarcoma genomics and new therapeutic targets.Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma.Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma.Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management.Comprehensive adipocytic and neurogenic tissue microarray analysis of NY-ESO-1 expression - a promising immunotherapy target in malignant peripheral nerve sheath tumor and liposarcoma.Liposarcoma: molecular genetics and therapeutics.Modeling sarcomagenesis using multipotent mesenchymal stem cells.RNA-binding proteins as molecular links between cancer and neurodegeneration.Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.Comparable transforming capacities and differential gene expression patterns of variant FUS/CHOP fusion transcripts derived from soft tissue liposarcomas.Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine.A mechanistic study on the metastasis inducing function of FUS-CHOP fusion protein in liposarcoma.Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.Establishing a patient-derived xenograft model of human myxoid and round-cell liposarcoma.Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.Mode of action of trabectedin in myxoid liposarcomas.Clinical and Molecular Spectrum of Liposarcoma.Presence of TERT Promoter Mutations is a Secondary Event and Associates with Elongated Telomere Length in Myxoid Liposarcomas.The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies.Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma.Hypermethylation of the APC promoter but lack of APC mutations in myxoid/round-cell liposarcoma.

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P2860

The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.

http://www.wikidata.org/entity/Q52168068

description

2000 nî lūn-bûn

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2000年の論文

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年學術文章

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2000年學術文章

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name

The chimeric FUS/TLS-CHOP fusi ...... posarcomas in transgenic mice.

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The chimeric FUS/TLS-CHOP fusi ...... posarcomas in transgenic mice.

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type

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The chimeric FUS/TLS-CHOP fusi ...... posarcomas in transgenic mice.

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The chimeric FUS/TLS-CHOP fusi ...... posarcomas in transgenic mice.

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prefLabel

The chimeric FUS/TLS-CHOP fusi ...... posarcomas in transgenic mice.

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The chimeric FUS/TLS-CHOP fusi ...... posarcomas in transgenic mice.

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The chimeric FUS/TLS-CHOP fusi ...... posarcomas in transgenic mice.

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Battaner E

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Bañares-González B

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Flores T

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Gutiérrez-Adán A

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Martín-Martín JF

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Pintado B

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Pérez-Losada J

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Sánchez-García I

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del Campo JC

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P2860

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene.

A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

pEF-BOS, a powerful mammalian expression vector

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2413-2422

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10.1038/SJ.ONC.1203572

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