Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.
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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingTherapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's diseaseHyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer diseaseUp-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's diseaseTau-tubulin kinaseThe Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeletonNeurodegeneration behind bars: from molecules to jurisprudenceToxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau DephosphorylationTau physiology and pathomechanisms in frontotemporal lobar degenerationInvolvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3betaPropofol directly increases tau phosphorylationMemantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive ImpairmentPreclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-MitoxyI1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2APin1 inhibition activates cyclin D and produces neurodegenerative pathologyEarly growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brainActivation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytesUtilizing the peptidyl-prolyl cis-trans isomerase pin1 as a probe of its phosphorylated target proteins. Examples of binding to nuclear proteins in a human kidney cell line and to tau in Alzheimer's diseased brain.Phosphorylation of tau is regulated by PKN.Cholesterol-dependent modulation of tau phosphorylation in cultured neurons.Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylationThe excitotoxin quinolinic acid induces tau phosphorylation in human neuronsRoles of tau protein in health and disease.Dysregulation of tau phosphorylation in mouse brain during excitotoxic damageAttenuation of okadaic acid-induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms.TDP-43 suppresses tau expression via promoting its mRNA instability.Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice.Mechanisms of tau-induced neurodegeneration.Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.N-glycosylation status of E-cadherin controls cytoskeletal dynamics through the organization of distinct β-catenin- and γ-catenin-containing AJs.Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state.Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments.Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau₄₅₋₂₃₀ transgenic mice.Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable mannerIdentification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization.A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease
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P2860
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh-hant
name
Phosphorylation of microtubule ...... ration in Alzheimer's disease.
@en
Phosphorylation of microtubule ...... ration in Alzheimer's disease.
@nl
type
label
Phosphorylation of microtubule ...... ration in Alzheimer's disease.
@en
Phosphorylation of microtubule ...... ration in Alzheimer's disease.
@nl
prefLabel
Phosphorylation of microtubule ...... ration in Alzheimer's disease.
@en
Phosphorylation of microtubule ...... ration in Alzheimer's disease.
@nl
P2093
P356
P1476
Phosphorylation of microtubule ...... ration in Alzheimer's disease.
@en
P2093
P304
P356
10.1074/JBC.275.8.5535
P407
P577
2000-02-01T00:00:00Z