Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
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Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes53BP2S, interacting with insulin receptor substrates, modulates insulin signalingProtein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signalingInsulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heartInteraction of p85 subunit of PI 3-kinase with insulin and IGF-1 receptors analysed by using the two-hybrid systemAssociation of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulinLocalization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating proteinA novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytesInsulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathyThe differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptorIRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosisGrb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its functionDisruption of the Fbxw8 gene results in pre- and postnatal growth retardation in miceSuppression of aging in mice by the hormone KlothoThe structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinaseSignal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylationGosha-jinki-gan (a Herbal Complex) Corrects Abnormal Insulin SignalingCardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium ChannelsInflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's DiseaseAge-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin SensitivityMolecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell DysfunctionInsulin receptor signaling in normal and insulin-resistant statesLessons from mouse models of high-fat diet-induced NAFLDGenetically modified mouse models for the study of nonalcoholic fatty liver diseaseMolecular basis of physiological heart growth: fundamental concepts and new playersThe combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescueTwo membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signalingHepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3Involvement of the PA28 -Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core ProteinThe Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated ProteinsShc and CEACAM1 interact to regulate the mitogenic action of insulinTyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulinInsulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-24PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient miceInsulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signalingBrown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistanceChronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytesHexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes
P2860
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P2860
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh-hant
name
Alternative pathway of insulin ...... disruption of the IRS-1 gene.
@en
Alternative pathway of insulin ...... disruption of the IRS-1 gene.
@nl
type
label
Alternative pathway of insulin ...... disruption of the IRS-1 gene.
@en
Alternative pathway of insulin ...... disruption of the IRS-1 gene.
@nl
prefLabel
Alternative pathway of insulin ...... disruption of the IRS-1 gene.
@en
Alternative pathway of insulin ...... disruption of the IRS-1 gene.
@nl
P2093
P356
P1433
P1476
Alternative pathway of insulin ...... disruption of the IRS-1 gene.
@en
P2093
P2888
P304
P356
10.1038/372186A0
P407
P577
1994-11-01T00:00:00Z
P6179
1049271444